Results 91 to 100 of about 7,676,849 (387)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Systematic review of the psychometric properties of patient-reported outcome measures for foot and ankle in rheumatoid arthritis [PDF]

, 2019
Background Foot problems and pain are common in patients with rheumatoid arthritis. Patient-reported outcome measures provide a standardized method of capturing patients’ perspectives of their functional status and wellbeing.
Cervera Garvi, Pablo, Gijón-Noguerón, Gabriel, Nester, Christopher J., Ortega-Avila, Ana Belen, Ramos Petersen, Laura   +4 more
core  

Added Value of Patient‐Reported Outcome Measures in Stroke Clinical Practice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThere is uncertainty regarding the clinical utility of the data obtained from patient‐reported outcome measures (PROMs) for patient care. We evaluated the incremental information obtained by PROMs compared to the clinician‐reported modified ...
Irene L. Katzan, Nicolas R. Thompson, Brittany Lapin, Ken Uchino   +3 more
doaj   +1 more source

Orthopaedic registries with patient-reported outcome measures

EFORT Open Reviews, 2019
Total joint arthroplasty is performed to decreased pain, restore function and productivity and improve quality of life. One-year implant survivorship following surgery is nearly 100%; however, self-reported satisfaction is 80% after total knee ...
I. Wilson, E. Bohm, A. Lübbeke, S. Lyman, S. Overgaard, O. Rolfson, A. W-Dahl, M. Wilkinson, M. Dunbar   +8 more
semanticscholar   +1 more source

Patient-Reported Outcomes in Cardiothoracic Surgery [PDF]

The Annals of Thoracic Surgery, 2019
Current studies in cardiothoracic clinical research frequently fail to use end points that are most meaningful to patients, including measures associated with quality of life. Patient-reported outcomes (PROs) represent an underused but important component of high-quality patient-centered care.
Subramanian, Melanie, Kozower, Benjamin D, Brown, Lisa M, Khullar, Onkar V, Fernandez, Felix G   +4 more
openaire   +5 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Protocol for a mixed-methods study to develop and feasibility test a digital system for the capture of patient-reported outcomes (PROs) in patients receiving chimeric antigen receptor T-cell (CAR-T) therapies (the PRO-CAR-T study)

BMJ Open
Introduction Chimeric antigen receptor (CAR) T-cell therapies are novel, potentially curative therapies for haematological malignancies. CAR T-cell therapies are associated with severe toxicities, meaning patients require monitoring during acute and ...
Christel McMullan, Melanie Calvert, Karen Shaw, Sarah E Hughes, Olalekan Lee Aiyegbusi, Elin Haf Davies, Charles Craddock, David Burns, Francesca Kinsella, Paul Ferguson, Foram Khatsuria, Lester Pyatt, John Ansell, Evelyn Chakera, Julie Richardson-Abraham   +14 more
doaj   +1 more source

The facilitators and barriers to implementing patient reported outcome measures in organisations delivering health related services: a systematic review of reviews

Journal of Patient-Reported Outcomes, 2018
BackgroundThere is increasing interest in using Patient Reported Outcome Measures (PROMs) within organisations delivering health related services. However, organisations have had mixed success in implementing PROMs and there is little understanding about
Alexis Foster, L. Croot, J. Brazier, Janet Harris, A. O’Cathain   +4 more
semanticscholar   +1 more source

Patients reported outcomes in thoracic surgery [PDF]

Journal of Thoracic Disease, 2018
Recent advances in early detection and targeted therapies of lung cancer have contributed to improve prognosis. In this context, the importance of preserving quality of life (QOL) of lung cancer survivors is compounded.
Pompili, C, Absolom, K, Velikova, G, Backhus, L   +3 more
openaire   +3 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source