Results 141 to 150 of about 11,226,138 (306)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Implementation of patient and public involvement and engagement (PPIE) for the therapies for long COVID in non-hospitalised individuals (TLC) project

Research Involvement and Engagement
Background Patients, their family members and caregivers have firsthand experiences of living with or supporting someone living with a disease or medical condition.
Olalekan Lee Aiyegbusi, Christel McMullan, Sarah E. Hughes, Grace M. Turner, Shamil Haroon, Richard Hotham, Kirsty Brown, Yvonne Alder, Lisa Agyen, Lewis Buckland, Jennifer Camaradou, Amy Chong, Felicity Jeyes, Karen L. Matthews, Patricia Moore, Jane Ormerod, Gary Price, Michael Saint-Cricq, David Stanton, Anita Walker, Melanie J. Calvert   +20 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Dry Eye dAily Life (DEAL) Questionnaire: Psychometric Validation of a New Instrument for Measuring the Impact of Dry Eye on Daily Life and Patient Satisfaction While Using Eye Drops

Clinical Ophthalmology
Martin Duracinsky,1,2 Alexandros Gryparis,3,4 Sarah Farrant,5 Ester Villalonga-Olives,6 Antonio J Mateo-Orobia,7,8 Olivier Chassany1,21Patient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP-HP,
Duracinsky M, Gryparis A, Farrant S, Villalonga-Olives E, Mateo-Orobia AJ, Chassany O   +5 more
doaj  

Self-management of long COVID symptoms with over-the-counter medicines and other non-prescribed therapies: a cross-sectional survey

BMC Public Health
Background The high prevalence of long COVID globally necessitates investigation into its self-management, especially given the absence of definitive and effective treatments and uneven access to healthcare services.
Naijie Guan, Grace Turner, Richard Hotham, Daniel Lange, Kirsty R. Brown, Christel McMullan, Sarah E. Hughes, Olalekan Lee Aiyegbusi, Karen Matthews, Louise Jackson, Asma Yahyouche, Yvonne Alder, Felicity Jeyes, Lewis Buckland, Amy Chong, David Stanton, Melanie Calvert, Shamil Haroon   +17 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The development and validation of a patient-reported outcome measure of health-related quality of life for patients with pressure ulcers: PUQOL Project [PDF]

, 2011
This thesis aimed to establish the impact of pressure ulcers (PUs) on health-related quality of life (HRQL) and determine the need for a PU-specific patient-reported outcome (PRO) instrument.
Gorecki, Claudia Anna
core   +1 more source

Patient-reported outcomes (PROs) in pancreatic islet transplantation : a systematic review

, 2010
Patient-reported outcomes (PROs) in pancreatic islet transplantation : a systematic ...
J Shaw (7798793), R Smith (7738349), A Woodcock (13712029), J Speight (7755977), M Reaney (13605682)   +4 more
core