Results 151 to 160 of about 11,226,138 (306)

Patient reported outcomes, patient reported outcome measures and genetic associations assessed.

, 2018
Patient reported outcomes, patient reported outcome measures and genetic associations assessed.
Jorge Gomes (2575600), Alda Marques (747276), Gabriela Moura (8052), Hélder Melro (5434703)   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hand and shoulder diagnoses are associated with substantial bodily pain compared to vascular complications and long-term glycaemic control in people with long-term type 1 diabetes.

Journal of Patient-Reported Outcomes
Background People with type 1 diabetes are burdened by musculoskeletal hand and shoulder diagnoses and vascular late complications. We aimed to explore associations of musculoskeletal diagnoses, 30-year HbA1c and vascular complications with pain, fatigue,
Anne Karin Molvær, Iversen Marjolein Memelink, Jannicke Igland, Mark Peyrot, Grethe S. Tell, Tore Julsrud Berg   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Optimising patient centred drug development to realise impact

Communications Medicine
Patient-reported outcomes can provide valuable evidence on the efficacy and tolerability of treatments throughout the drug development pipeline supporting regulatory decision-making, reimbursement and patient-centred care. Use of international guidelines
Melanie Calvert, Paul Kamudoni, Christina Yap, Claire Snyder, Roger Wilson, Olalekan Lee Aiyegbusi   +5 more
doaj   +1 more source

Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease

Background: Late-onset Pompe disease (LOPD), a rare autosomal recessive multisystemic disorder, substantially impacts patients' day-to-day activities, outcomes, and health-related quality of life (HRQoL).
Diaz-Manera, Jordi, Butler, Ernest, Hummel, Noemi, Hiwot, Tarekegn, Attarian, Shahram, Akihiro, Hashiguchi, Laszlo, Vescei, Kim, Gee, Roxburgh, Richard, Tchan, Michel, on behalf of the PROPEL Study Group, Papadimas, George Konstantinos, Henderson, Robert, Stefanescu, Ela, Lau, Heather, Amartino, Hernán, Hughes, Derralynn, Lindberg, Christopher, Bodkin, Cynthia, Tard, Celine, Byrne, Barry J., Shohet, Simon, Freimer, Miriam, Löscher, Wolfgang, Hopkin, Robert, Reyes-Leiva, David, Pedro, Helio, Avelar, Jennifer, Musumeci, Olimpia, Vidal-Fernandez, Nuria, Parenti, Giancarlo, Cauci, Jonathan, Molnar, Maria Judit, Sebok, Agnes, Khan, Aneal, Tarnopolsky, Mark, Shiraishi, Hideaki, Andersen, Henning, Toscano, Antonio, Wencel, Marie, Shin, Jin-Hong, Dearmey, Stephanie, Kobayashi, Hiroshi, Kornblum, Cornelia, Bartosik-Psujek, Halina, Wenninger, Stephan, Janszky, Jozsef, Schoser, Benedikt, Dominovic-Kovacevic, Aleksandra, Kushlaf, Hani, Fecarotta, Simona, Alonso-Pérez, Jorge, Quinn, Colin, Ruck, Tobias, Burrow, Thomas, Kishnani, Priya S., Vengoechea, Jaime, Mozaffar, Tahseen, Claeys, Kristl, Clemens, Paula R, Roberts, Mark, Deegan, Patrick, Bouhour, Francoise, Koritnik, Blaž, Pestronk, Alan, Gutschmidt, Kristina, Kopiec, Agnieszka, Sawada, Tomo, Salort-Campana, Emmanuelle, Eldridge, Crystal, Claeys, Kristl G., Chien, Yin-Hsiu, Holdbrook, Fred, Longo, Nicola, Goker-Alpan, Ozlem, Sacconi, Sabrina, Universitat Autònoma de Barcelona, Dimachkie, Mazen M., Tarnev, Ivaylo, Berthy, Julie, Clemens, Paula R.   +80 more
core   +1 more source

Patient-reported outcomes in the spotlight [PDF]

The Lancet Neurology, 2019
openaire   +2 more sources