Results 161 to 170 of about 2,568,476 (309)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Conical Implants in Tuberous Breast Correction: Clinical and Patient-Reported Outcomes. [PDF]

Medicina (Kaunas)
González-Prieto J, González-Nicolás A, Barcaro Machado BH.   +2 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Patient-reported outcomes of ocriplasmin for the treatment of vitreomacular traction: a systematic review and synthesis of the literature

, 2019
Benedicte Lescrauwaet,1 Koenraad Blot,2 Timothy L Jackson3 1Xintera, Outcomes Research, Ghent, Belgium; 2Xintera, Ghent, Belgium; 3Life Sciences and Medicine, King’s College London, Department of Ophthalmology, King’s College Hospital, London,
Lescrauwaet B, Jackson TL, Blot K
core  

High Versus Low Radiographic Burden Odontogenic Sinusitis: Culture, Histopathology, and Patient-Reported Outcomes. [PDF]

Laryngoscope Investig Otolaryngol
Ebbert LE, Kumar N, Lal D, Miglani A, Marino MJ.   +4 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Patient-reported outcomes in pancreatic islet transplantation : a systematic review

, 2009
Patient-reported outcomes in pancreatic islet transplantation : a systematic ...
J Shaw (7798793), R Smith (7738349), A Woodcock (13712029), J Speight (7755977), M Reaney (13605682)   +4 more
core  

Switching treatment to cipaglucosidase alfa plus miglustat positively affects patient-reported outcome measures in patients with late-onset Pompe disease

Background: Late-onset Pompe disease (LOPD), a rare autosomal recessive multisystemic disorder, substantially impacts patients' day-to-day activities, outcomes, and health-related quality of life (HRQoL).
Diaz-Manera, Jordi, Butler, Ernest, Hummel, Noemi, Hiwot, Tarekegn, Attarian, Shahram, Akihiro, Hashiguchi, Laszlo, Vescei, Kim, Gee, Roxburgh, Richard, Tchan, Michel, on behalf of the PROPEL Study Group, Papadimas, George Konstantinos, Henderson, Robert, Stefanescu, Ela, Lau, Heather, Amartino, Hernán, Hughes, Derralynn, Lindberg, Christopher, Bodkin, Cynthia, Tard, Celine, Byrne, Barry J., Shohet, Simon, Freimer, Miriam, Löscher, Wolfgang, Hopkin, Robert, Reyes-Leiva, David, Pedro, Helio, Avelar, Jennifer, Musumeci, Olimpia, Vidal-Fernandez, Nuria, Parenti, Giancarlo, Cauci, Jonathan, Molnar, Maria Judit, Sebok, Agnes, Khan, Aneal, Tarnopolsky, Mark, Shiraishi, Hideaki, Andersen, Henning, Toscano, Antonio, Wencel, Marie, Shin, Jin-Hong, Dearmey, Stephanie, Kobayashi, Hiroshi, Kornblum, Cornelia, Bartosik-Psujek, Halina, Wenninger, Stephan, Janszky, Jozsef, Schoser, Benedikt, Dominovic-Kovacevic, Aleksandra, Kushlaf, Hani, Fecarotta, Simona, Alonso-Pérez, Jorge, Quinn, Colin, Ruck, Tobias, Burrow, Thomas, Kishnani, Priya S., Vengoechea, Jaime, Mozaffar, Tahseen, Claeys, Kristl, Clemens, Paula R, Roberts, Mark, Deegan, Patrick, Bouhour, Francoise, Koritnik, Blaž, Pestronk, Alan, Gutschmidt, Kristina, Kopiec, Agnieszka, Sawada, Tomo, Salort-Campana, Emmanuelle, Eldridge, Crystal, Claeys, Kristl G., Chien, Yin-Hsiu, Holdbrook, Fred, Longo, Nicola, Goker-Alpan, Ozlem, Sacconi, Sabrina, Universitat Autònoma de Barcelona, Dimachkie, Mazen M., Tarnev, Ivaylo, Berthy, Julie, Clemens, Paula R.   +80 more
core   +1 more source

Digitization of Patient-Reported Outcomes [PDF]

Value in Health, 2013
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source