Results 221 to 230 of about 7,712,957 (388)
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau+11 more
wiley +1 more source
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit+19 more
wiley +1 more source
Interplay of integrins and selectins in metastasis
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva+2 more
wiley +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson+11 more
wiley +1 more source
Patient-reported outcomes for remote and in-person visits for genetic counseling in adult neurology. [PDF]
Paul RA+8 more
europepmc +1 more source
Poster 210 successful outcome of a pediatric patient with eastern equine encephalitis, despite a high morbidity and mortality rate associated with the disease: A case report. Clinton Faulk, MD (Pitt County Mem Hosp, Greenville, NC); Billy Smith, MD; Daniel Moore, MD, e-mail: cjmfaulk@yahoo.com [PDF]
openalex +1 more source
Oh, the Places We’ll Go: Patient-Reported Outcomes and Electronic Health Records
Sarah G. Gensheimer+4 more
semanticscholar +1 more source