Results 71 to 80 of about 6,836,441 (345)

Content validity and meaningful change for the FACIT-Fatigue scale in warm autoimmune hemolytic anemia: results from qualitative interview studies with patients

Journal of Patient-Reported Outcomes
Purpose Warm autoimmune hemolytic anemia (wAIHA) is a rare disorder characterized by premature destruction of red blood cells (hemolysis) and fatigue that affects patients’ health-related quality of life.
Sheryl Pease, Rikki Mangrum, Karolina Schantz, Christina Slota, Lindsey Rubin, Susan Martin, Cathye Shu, Kayla Scippa   +7 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Impact of missing data on bias and precision when estimating change in patient-reported outcomes from a clinical registry

Health and Quality of Life Outcomes, 2019
BackgroundClinical registries, which capture information about the health and healthcare use of patients with a health condition or treatment, often contain patient-reported outcomes (PROs) that provide insights about the patient’s perspectives on their ...
O. Ayilara, Lisa Zhang, T. Sajobi, R. Sawatzky, E. Bohm, L. Lix   +5 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Literature review to assemble the evidence for response scales used in patient-reported outcome measures

Journal of Patient-Reported Outcomes, 2018
Background In the development of patient-reported outcome (PRO) instruments, little documentation is provided on the justification of response scale selection.
Katharine Gries, Pamela Berry, Magdalena Harrington, Mabel Crescioni, Mira Patel, Katja Rudell, Shima Safikhani, Sheryl Pease, Margaret Vernon   +8 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Enhancing representativeness of patient-reported outcomes in routine radiation oncology care: a quality improvement protocol to address non-response

BMJ Open
Introduction Non-response significantly undermines the representativeness of patient-reported outcome (PRO) data, thereby compromising its utility for facilitating high-value, equitable, patient-centred care in cancer clinics. Quality improvement studies
Andrea L Pusic, Jason B Liu, Chengbo Zeng, Neil E Martin, Maria O Edelen   +4 more
doaj   +1 more source

International phase 1 study protocol to develop a health state classification system for a preference-based measure for women with breast cancer: the BREAST-Q Utility module

BMJ Open, 2020
Introduction Concerns unique to women with breast cancer can include impact of cancer on body image, sexual well-being and changes in breast appearance and sensation.
Andrea L Pusic, Stefan J Cano, Anne Klassen, Feng Xie, Manraj Kaur, Louise Bordeleau   +5 more
doaj   +1 more source

Levels of health literacy among people living with HIV in outpatient care: a cross-sectional study from Denmark

AIDS Research and Therapy, 2023
Background Low health literacy (HL) among people living with HIV (PLWHIV) encounter more disease related complications, more difficulty understanding health-related information and low adherence.
Lotte Ørneborg Rodkjaer, Merete Storgaard, Nanna Toxvig Sørensen, Liv Marit Valen Schougaard   +3 more
doaj   +1 more source

Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items

Quality of Life Research, 2009
BackgroundThe use of global health items permits an efficient way of gathering general perceptions of health. These items provide useful summary information about health and are predictive of health care utilization and subsequent mortality ...
R. Hays, J. Bjorner, D. Revicki, K. Spritzer, D. Cella   +4 more
semanticscholar   +1 more source