Results 91 to 100 of about 687,161 (310)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Role of Computerized Physician Order Entry Usability in the Reduction of Prescribing Errors [PDF]

, 2013
Some hospitals have implemented computerized physician order entry (CPOE) systems to reduce the medical error rates. However, research in this area has been very limited, especially regarding the impact of CPOE use on the reduction of prescribing errors.
Elhissi, Abdelbary, Peikari, Hamid Reza, Shah, Mahmood, Yasin, Norjaya M., Zakaria, Mohamad Shanudin   +4 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Determining Factors Affecting Nurses’ Acceptance of a Care Plan System Using a Modified Technology Acceptance Model 3: Structural Equation Model With Cross-Sectional Data

JMIR Medical Informatics, 2020
BackgroundHealth information technology is used in nursing practice worldwide, and holistic patient care planning can serve as a guide for nursing practice to ensure quality in patient-centered care.
Ho, Kuei-Fang, Chang, Pi-Chen, Kurniasari, Maria Dyah, Susanty, Sri, Chung, Min-Huey   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dutch GP healthcare consumption in COVID-19 heterogeneous regions: an interregional time-series approach in 2020–2021

BJGP Open
Background: Many countries observed a sharp decline in the use of general practice services after the outbreak of the COVID-19 pandemic. However, research has not yet considered how changes in healthcare consumption varied among regions with the same ...
Maarten Homburg, Marjolein Berger, Matthijs Berends, Eline Meijer, Thijmen Kupers, Lotte Ramerman, Corinne Rijpkema, Evelien de Schepper, Tim olde Hartman, Jean Muris, Robert Verheij, Lilian Peters   +11 more
doaj   +1 more source

For the benefit of others: reasons why women with breast cancer participate in RCTs [PDF]

, 2015
Introduction: Appreciation of the barriers and drivers affecting enrolment in randomised clinical trials (RCTs) is important for future trial design, communication and information provision.
Fallowfield, Lesley, Jenkins, Valerie
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cytotoxic chemotherapy for incurable colorectal cancer: living with a PICC-line [PDF]

, 2008
<b>Aims.</b> (i) To determine which aspects of living with a peripherally inserted central catheter (PICC) line cause Modified de Gramont (MdG) patients most difficulty. (ii) To explore MdG patients' views of the PICC-line experience.
Agence D’evaluation des Technologies et des Modes D’intervention en Sante (AETMIS), Borras, Carlson, Chernecky, Collins, de Gramont, Dobson, Elf, Gabriel, Gabriel, Galloway, Holloway, Jenkins, Kruijver, Leonard, marc: Management and Awareness of the Risk of Cytotoxics, McCaughan, Moureau, National Institute for Health and Clinical Evidence, Oakley, Oppenheim, Ost, Philpot, Polit, Priest, Scottish Intercollegiate Guidelines Network, SEHD, Sitzia, Skalla, Twelves C in SEHD, UK Parliament, WHO, Young   +32 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source