Results 81 to 90 of about 259,533 (276)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Dutch GP healthcare consumption in COVID-19 heterogeneous regions: an interregional time-series approach in 2020–2021

BJGP Open
Background: Many countries observed a sharp decline in the use of general practice services after the outbreak of the COVID-19 pandemic. However, research has not yet considered how changes in healthcare consumption varied among regions with the same ...
Maarten Homburg, Marjolein Berger, Matthijs Berends, Eline Meijer, Thijmen Kupers, Lotte Ramerman, Corinne Rijpkema, Evelien de Schepper, Tim olde Hartman, Jean Muris, Robert Verheij, Lilian Peters   +11 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The association of oral health knowledge with the behavior of pregnant women visiting the dentist based on the theory of planned behavior: Cross-sectional studies

Padjadjaran Journal of Dentistry
Introduction: A lack of knowledge of oral health maintenance among pregnant women affects the behavior of maintaining poor oral health.  It is important for pregnant women to visit the dentist due to their increased susceptibility to oral diseases, which
Dikkara Rizqi, Netty Suryanti, Anne Agustina Suwargiani, Niekla Survia Andiesta   +3 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Barriers to treatment: describing them from a different perspective

Patient Preference and Adherence, 2018
Francesca Devine,1 Taylor Edwards,1 Steven R Feldman1–3 1Center for Dermatology Research, Department of Dermatology, 2Department of Pathology, 3Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC ...
Devine F, Edwards T, Feldman SR
doaj  

Managerial practices for app-based primary care telemedicine service acceptance in South Africa

South African Journal of Business Management
Purpose: This study addresses the qualitative research phase of a mixed methods study conducted to investigate patient acceptance of an app-based telemedicine service for primary care aimed at South African public health care sector patients.
Grethe van Tonder, Ronel du Preez, Christian D. Pentz   +2 more
doaj   +1 more source

Acceptability, Feasibility and Appropriateness of Care of Patients with Depression at Health and Wellness Centre in a District of India

Preventive Medicine: Research & Reviews
AbstractObjective:To study implementation of mental health services delivery with depression as tracer condition through Health and Wellness Centres (HWCs) under Ayushman Bharat programme in India.Materials and Methods:Mixed methods approach. The outcomes of acceptability, appropriateness and feasibility were measured and analysed.Results:The study ...
Sourabh Saxena, Anant Bhan, William Fleming, Abhishek Singh, Deepak Tugnawat   +4 more
openaire   +2 more sources