Results 91 to 100 of about 1,590,116 (307)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Implicit cognition is impaired and dissociable in a head-injured group with executive deficits [PDF]

, 2005
Implicit or non-conscious cognition is traditionally assumed to be robust to pathology but Gomez-Beldarrain et al (1999, 2002) recently showed deficits on a single implicit task after head injury.
Andrade, J., Barker, L.A., Morton, N., Romanowski, C.A.J., Wasti, A.   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Evaluation of uptake and effect on patient-reported outcomes of a clinician and patient co-led chronic musculoskeletal pain self-management programme provided by the UK National Health Service [PDF]

, 2017
In the United Kingdom, chronic pain affects approximately 28 million adults, creating significant healthcare and socio-economic costs. The aim was to establish whether a programme designed to use best evidence of content and delivery will be used by ...
Anderson, Joanna K, Wallace, Louise M.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Feasibility of Remote Patient Peer Mentoring in Hemodialysis

Kidney Medicine, 2022
Paul N. Bennett, BN, MHSM, GCSc(AppStats), PhD, Wael F. Hussein, MBBS, MSc, MRCPI, Marissa Argentina, LMSW, Kelli C. Damron, MSW, Jugjeet Atwal, Brigitte Schiller, MD   +5 more
doaj   +1 more source

Patient activation in individuals with type 2 diabetes mellitus: associated factors and the role of insulin

Patient Preference and Adherence, 2018
Heidi A van Vugt,1,2,* Anne Meike Boels,1,* Inge de Weerdt,2 Eelco JP de Koning,3 Guy EHM Rutten1 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3508 GA Utrecht, Utrecht, the Netherlands ...
van Vugt HA, Boels AM, de Weerdt I, de Koning EJP, Rutten GEHM   +4 more
doaj  

The simulation of action disorganisation in complex activities of daily living [PDF]

, 2005
Action selection in everyday goal-directed tasks of moderate complexity is known to be subject to breakdown following extensive frontal brain injury. A model of action selection in such tasks is presented and used to explore three hypotheses concerning ...
Anderson JR, Cooper RP, Cooper RP, Duncan J, Fuster JM, Grafman J, Houghton G, Houghton G, Humphreys GW, Humphreys GW, Liepmann H, Luria AR, McClelland JL, Myrna F. Schwartz, Norman DA, Norman DA, Passingham RE, Peter Yule, Pick A, Poeck K, Reason JT, Reason JT, Richard P. Cooper, Rumiati RI, Schwartz MF, Shallice T, Sirigu A, Tim Shallice, Verfaellie M, Williams RJ, Yule P, Zipf GK   +31 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Mobile App for Chronic Disease Self-Management for Individuals with Low Health Literacy: A Multisite Randomized Controlled Clinical Trial

Journal of Ageing and Longevity
The purpose of this study was to evaluate the effects of a mobile app designed to improve chronic disease self-management in patients aged 40 years and older with low health literacy and who had at least one chronic health condition, and to assess the ...
Raymond L. Ownby, Michael Simonson, Joshua Caballero, Kamilah Thomas-Purcell, Rosemary Davenport, Donrie Purcell, Victoria Ayala, Juan Gonzalez, Neil Patel, Kofi Kondwani   +9 more
doaj   +1 more source