Results 51 to 60 of about 224,959 (261)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Wonderings to research questions: Engaging patients in long COVID research prioritization within a learning health system

Learning Health Systems
Background An integral component of research within a learning health system is patient engagement at all stages of the research process. While there are well‐defined best practices for engaging with patients on predetermined research questions, there is
Ann Blair Kennedy, Ariana Mitcham, Katherine Parris, Faith Albertson, Luis Sanchez Ferrer, Conor O'Boyle, Maushmi K. Patel, Tracey Gartner, Amy M. Broomer, Evan Katzman, Jeanette Coffin, Jennifer T. Grier, Nabil Natafgi   +12 more
doaj   +1 more source

Not Surprising: Patients Not Engaged and Not Using Public Healthcare Quality Information [PDF]

The Patient - Patient-Centered Outcomes Research, 2016
Upon reading the paper published in this issue of The Patient: Patient-Centered Outcomes Research [1] on public reports for vulnerable populations living with diabetes mellitus, I reacted with surprise to the observation that ‘‘patients have not been systematically engaged in the development, design, and dissemination of publicly available reports on ...
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Incorporating patient and public involvement (PPI) at the design stage of an early career physiotherapy researcher's funding application: A co-produced reflective case report

Social Sciences and Humanities Open
Aim: Patient and public involvement (PPI) in health and social care research is a requirement of nationally peer reviewed funders and the National Institute for Health Research (NIHR), including research grant applications.
Jacqueline Bennion, Roger Garrett, Mark Hudson, Ian Taylor, Cathy Taylor, Duncan Barron   +5 more
doaj   +1 more source

Recruiting patients as partners in health research: a qualitative descriptive study

Research Involvement and Engagement, 2017
Plain English summary Increasingly, funders and researchers want to partner with patients in health research, but it can be challenging for researchers to find patient partners.
Lidewij Eva Vat, Devonne Ryan, Holly Etchegary   +2 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Co‐Creation of a Study Protocol to Assess the Effect of Transcranial Direct Current Stimulation in the Management of Fatigue in Children and Young People With Acquired Brain Injury (Fatiguebrain‐tDCS)

Health Expectations
Background Children and young people (CYP) with moderate/severe acquired brain injury (ABI) often have problems with chronic cognitive fatigue. Methylphenidate, a controlled drug, and cognitive behavioural therapy have been used to manage fatigue, but ...
Chandrasekar Rathinam, Gemma Heath, Rajat Gupta, Evangeline Wassmer, Emily McElroy, Helen Horn, Davinia Fernandez‐Espejo   +6 more
doaj   +1 more source

Negotiating research in the Emergency Department: a qualitative study of staff experience of the Distal Radius Acute Fracture Trial CAst versus SPlint (DRAFT3-CASP) RCT for distal radius fractures

Bone & Joint Open
Aims: We sought to explore staff experience of conducting an orthopaedic trauma randomized controlled trial (RCT) in the Emergency Department (ED). The Distal Radius Acute Fracture Trial: CAst versus SPlint (DRAFT3-CASP) RCT explores the effectiveness of
Emma E. Phelps, Elizabeth Tutton, Jenny Gould, Liz Baird, Juul Achten, Matthew L. Costa   +5 more
doaj   +1 more source

Using the UK standards for public involvement to evaluate the public involvement sections of annual reports from NIHR managed research centres

Research Involvement and Engagement, 2023
Background Within the United Kingdom (UK), the National Institute for Health and Care Research is the largest funder of health and social care research, and additionally funds research centres that support the development and delivery of research.
Alice Moult, Dereth Baker, Ali Aries, Paul Bailey, Steven Blackburn, Tom Kingstone, Saumu Lwembe, Zoe Paskins   +7 more
doaj   +1 more source