Results 41 to 50 of about 224,959 (261)

Series: Public engagement with research. Part 1: The fundamentals of public engagement with research

European Journal of General Practice, 2023
Background In the first of a four-part series, we describe the fundamentals of public engagement in primary care research.Objectives The article’s purpose is to encourage, inform and improve the researcher’s awareness about public engagement in research.
Steven Blackburn, Megan Clinch, Maarten de Wit, Albine Moser, Jette Primdahl, Esther van Vliet, Christine Walker, Fiona Stevenson   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Commentary: Advocating for patient and public involvement and engagement in health economic evaluation

Research Involvement and Engagement, 2023
Background Patient and public involvement in health economic evaluation is still relatively rare, compared to other areas of health and social care research.
Sophie Staniszewska, Ivett Jakab, Eric Low, Jean Mossman, Phil Posner, Don Husereau, Richard Stephens, Michael Drummond   +7 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Online comic-based art workshops as an innovative patient and public involvement and engagement approach for people with chronic breathlessness

Research Involvement and Engagement, 2023
Plain English summary Talking about breathlessness can be difficult and cause feelings of anxiety. Involving people with breathlessness in research activities can also be challenging.
Samantha L. Harrison, Julian Lawrence, Sophie Suri, Tim Rapley, Kirsti Loughran, James Edwards, Louise Roberts, Denis Martin, Joanne E. Lally   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Implementing and Delivering Culturally Centred Pharmacy Services Tailored to Ethnically Minoritised Populations: A Qualitative Systematic Review and Meta‐Ethnography

Health Expectations
Introduction Health inequities disproportionately affect people from ethnic minority communities and require a comprehensive effort across healthcare disciplines to tackle them.
Caitlin Shaw, Ghalib Khan, Thorrun Govind, Anna Robinson‐Barella   +3 more
doaj   +1 more source

Patients as partners in medical publications: the ISMPP journey of engagement

Current Medical Research and Opinion
Patient engagement (PE) has evolved from an emerging concept to a fundamental ethos underpinning healthcare research and communication. In this commentary, we explore the historical evolution in medical research from patients being participants in clinical trials to becoming integral partners in communicating medical research findings.
Simon R. Stones, Dawn Lobban, Catherine Skobe, Nichola Gokool, Trishna Bharadia, Anna Geraci, Robert J. Matheis   +6 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Adapting a brief mindful breathing intervention for self-management of distress in advanced cancer patients: the RESOLVE-i study

BMC Palliative Care
Background Psychological distress is common among patients with advanced cancer and can be a barrier to effective symptom management. Despite national guidance, psychological support in UK palliative care remains limited.
Carole A. Paley, Max Henderson, Sheila Freeman, Cornelia Reyes Acosta, Lucy Ziegler, Emma J. Chapman   +5 more
doaj   +1 more source