Results 171 to 180 of about 975,488 (355)

Co-developing an intervention to facilitate safe and early transition to neonatal home care for very preterm infants: a mixed-method study evaluating the impact of patient and public involvement

Research Involvement and Engagement
Background Very preterm born infants face elevated risks of adverse neurodevelopmental outcomes, with prolonged hospitalisation associated with poorer cognitive, motor, and language development.
Sofia Arwehed, Ylva Thernström Blomqvist, Elin Carlsson Filipowicz, Anna Axelin   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Unmasking oral health stigma: a qualitative scoping review

BMC Oral Health
Introduction Health-related stigma can limit access to care, impair adherence to treatment, and negatively impact mental health and quality-of-life. Oral health stigma, defined as stigma arising from oral conditions that diverge from sociocultural norms,
J. Doughty, J. Booth, M. Smith, K. Saini, M. Paisi, A. Rodriguez, A. Levine, C. Bedos, V. Muirhead, C. Martins de Barros, C. Freeborn   +10 more
doaj   +1 more source

Patient and Public Involvement in AMED

Annals of Oncology, 2019
Abstract Japan Agency for Medical Research and Development (AMED), established in 2015, is a funding agency that aims to act as a ’control tower’ that directs integrated research, from basic research to practical application. Also, our goal is to fast-track medical R&D that directly benefit people, not only by expending lifespans, but also improving
openaire   +1 more source

Addressing health literacy in patient decision aids

, 2013
MethodsWe reviewed literature for evidence relevant to these two aims. When high-quality systematic reviews existed, we summarized their evidence.
Clayman, M.L., Holmes-Rovner, M., Kelly-Blake, K., McCaffery, K., Nutbeam, Don, Rovner, D., Smith, S., Stacey, S., Wolf, M.   +8 more
core   +2 more sources

Considerations for patient and public involvement and engagement in health research

Nature Medicine, 2023
O. Aiyegbusi, C. McMullan, S. Hughes, G. Turner, A. Subramanian, Richard Hotham, E. Davies, Christopher Frost, Y. Alder, L. Agyen, Lewis Buckland, J. Camaradou, Amy Chong, Felicity Jeyes, Sumit Kumar, K. Matthews, Patricia Moore, Jane Ormerod, G. Price, M. Saint-Cricq, David Stanton, Anita Walker, S. Haroon, A. Denniston, M. Calvert, Kirsty Joht Singh Georgios V. Louise J. Janet M. Tom Stev Brown Chandan Gkoutos Jackson Lord Marshall Marwah, Kirsty R Brown, J. Chandan, G. Gkoutos, Louise J. Jackson, J. Lord, T. Marshall, S. Marwaha, P. Myles, K. Nirantharakumar, Samantha Cruz Rivera, Elizabeth Sapey, N. Simms-Williams, T. Williams, D. Wraith   +39 more
semanticscholar   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

“If it all goes digital, we’ll have to learn”: facilitators and barriers to uptake of digital health in British South Asians with cardiometabolic disease

BMC Digital Health
Background Although availability and utilisation of digital health interventions (DHIs) for management of diabetes and cardiovascular disease (“cardiometabolic disease”) have increased, they may exacerbate health inequalities. South Asians have increased
Mel Ramasawmy, David Sunkersing, Dan Roland Persson, Lydia Poole, Kiran Patel, Shivali Modha, Madiha Sajid, Paramjit Gill, Fiona Stevenson, Nushrat Khan, Amitava Banerjee   +10 more
doaj   +1 more source