Results 31 to 40 of about 358,401 (266)
Wellcome Open ResearchBackground Patient and public involvement and engagement (PPIE) in research is a collaboration between researchers, patients, and the public, enhancing research acceptability, relevance, and impact.
Monaza Khan +11 more
doaj +1 more source
Patient and public involvement in clinical trials [PDF]
BMJ, 2008 Is established worldwide, but encouragement is needed to promote institutional collaboration and avoid duplication of ...
openaire +2 more sources
MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou +9 more
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
What matters most in acute care: an interview study with older people living with frailty
BMC Geriatrics, 2022 Background Healthcare outcome goals are central to person-centred acute care, however evidence among older people is scarce. Older people who are living with frailty have distinct requirements for healthcare delivery and have distinct risk for adverse ...
James David van Oppen +8 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The 20 m shuttle run is not a valid test of cardiorespiratory fitness in boys aged 11–14 years
BMJ Open Sport & Exercise Medicine, 2019 Objectives The 20 m shuttle run test (20mSRT) is used to estimate cardiorespiratory fitness (CRF) through the prediction of peak oxygen uptake (V˙O2), but its validity as a measure of CRF during childhood and adolescence is questionable.
Jo Welsman, Neil Armstrong
doaj +1 more source
HRB Open Research, 2022 Background: Cerebral palsy (CP) is a common cause of physical disability in childhood. The majority of children with CP survive to adulthood. Once discharged from children’s services, adults with CP find it challenging to navigate health services.
Fiona Weldon +7 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Integration of patient and public involvement in a doctoral research study using the research cycle
Research Involvement and EngagementBackground Patient and public involvement (PPI) in research is widely acknowledged as essential to achieving successful and impactful research. Despite this acknowledgement, there are limited reports on how to approach and apply meaningful PPI throughout
Helen Pearson +9 more
doaj +1 more source