Results 101 to 110 of about 99,154 (254)

Understanding health care professionals’ barriers and facilitators to supporting the management of food allergy in British South Asian adults: Qualitative results from the FAIR Study

Journal of Allergy and Clinical Immunology: Global
Background: The burden of food allergy (FA) is greater among South Asian (SA) individuals in high-income countries. Objective: We sought to investigate facilitators/barriers for health care professionals (HCPs) in FA management in SA patients.
Gurkiran Birdi, PhD, Clare Stradling, PhD, Tammy-Jae Jaynes, Julianne Ponan, MBE, Melissa Singh, MSc, Sarah Baker, BEd (Hons), RGN, RSCN, RHV, Amena Warner, Christina J. Jones, PhD, Mamidipudi T. Krishna, PhD, FRCP, FRCPath   +8 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Amplifying the voices of Black racial minorities in mental health research through public involvement and engagement: The importance of advisory roles

Health Expectations
Introduction Ensuring adequate representation and the active, meaningful and visible involvement of groups likely to be most impacted by research findings and/or the lack of research inquiry are increasingly acknowledged.
Juliana Onwumere, Anthony Gentle, Rachel Obanubi, Annette Davis, Moffat Karuga, Rubbia Ali, BeFine Study Team, Valentina Cardi   +7 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Patient-oriented research– it’s personal: two BC SUPPORT unit patient partners sharing their journey in patient-oriented research

Research Involvement and Engagement
Plain English Summary Patient-oriented research is becoming an established way of healthcare research in Canada. It is supported by the Strategy for Patient-oriented Research (SPOR), launched by the Canadian Institutes of Health Research.
Lisa Ridgway, Sunny Loo
doaj   +1 more source

AIM RSF: Public and Patient Involvement and Engagement Activities

Presentation on Public and Patient Involvement and Engagement (PPIE) activities supported by the AI for Multiple Long-Term Conditions Research Support Facility. This presentation was delivered as part of HealthFest and gives a high level introduction to the workstreams undertaken by the PPIE team and AIM Research Consortia. 
openaire   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Celebrating and Recognising Excellence in Patient & Public Engagement and Involvement

This talk was presented as part of the conference titled ‘Pioneering AI in Multiple Long-Term Conditions: Bridging Research and Practice,’ held on 9-10 September and organised by AIM RSF. The conference provided an opportunity for the AI and multiple long-term conditions (MLTC) community to come together, including AIM researchers, data scientists ...
openaire   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source