Results 111 to 120 of about 99,154 (254)

Introducing Talking Health

International Journal of Integrated Care, 2014
Julia Stackhouse, Sara Price, Helen Peggs   +2 more
doaj   +3 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Development of the RIPPLES framework for patient and public involvement in rapid evidence syntheses

Research Involvement and Engagement
Background Patient and public involvement (PPI) is an expectation and requirement of health and social care research within the United Kingdom. Although there is available guidance on how to practice PPI, to date there have been no frameworks or ...
Eugenie Evelynne Johnson, Sean Gill, Madeleine Still, Daisy Trenchard, Debbie Smith, Rebecca Harmston, Jane McDermott, Fiona Pearson   +7 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Future directions for patient engagement in research: a participatory workshop with Canadian patient partners and academic researchers

Health Research Policy and Systems
Background Patient engagement in research (also commonly referred to as patient or patient and public involvement in research) strives to transform health research wherein patients (including caregivers and the public) are regularly and actively engaged ...
Anna Maria Chudyk, Roger Stoddard, Todd A. Duhamel, Patient Engagement in Research Partners, Annette S. H. Schultz   +4 more
doaj   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Patient and public involvement and engagement in critical care clinical research: A review

Australian Critical Care
Across the world, there is increasing recognition of the importance of engaging with and involving patients, family members and members of the public in the design, delivery and dissemination of clinical research. This reflects the value of grounding research in lived experience, thereby ensuring the relevance and integrity of the research.
Keith Couper, Teresa Melody, Marion Thompson, Louise Rose   +3 more
openaire   +3 more sources

Eastern England SDE Public and Patient Involvement and Engagement (PPIE) Learnings

This report outlines how the Eastern England Secure Data Environment (EE‑SDE) embedded meaningful Patient and Public Involvement and Engagement (PPIE) throughout the VISTA project. The aims of VISTA were to support and enhance existing EE-SDE processes, demonstrating how large-scale AI-enabled research can be conducted safely, efficiently and ...
Makachiya, Elsie, Adamson, Jack, Joannides, Alexis, Hall, Eleanor   +3 more
openaire   +1 more source