Results 51 to 60 of about 591,763 (265)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Prognostication of treatment non-compliance among patients with multidrug-resistant tuberculosis in the course of their follow-up: a logistic regression–based machine learning algorithm [PDF]

, 2023
Denekew Tenaw Anley, Temesgen Yihunie Akalu, Anteneh Mengist Dessie, Rahel Mulatie Anteneh, Melkamu Aderajew Zemene, Wubet Alebachew Bayih, Yenealem Solomon, Natnael Atnafu Gebeyehu, Gizachew Ambaw Kassie, Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Mohammed Abdu Seid, Molalegn Mesele Gesese, Natnael Moges, Berihun Bantie, Sefineh Fenta Feleke, Tadesse Asmamaw Dejenie, Getachew Asmare Adella, Achenef Asmamaw Muche   +18 more
openalex   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

Frequency of Compliance with Antidepressants using Antidepressant Compliance Questionnaire

Journal of Islamic International Medical College, 2012
Objective: To find out the frequency of compliance of patients using anti-depressants prescribed at out-patient department. Study Design: Descriptive cross sectional study.
Shahid Ali Khan, Muhammad Munir Ahmed, Imran Ahmed, Fareed Aslam Minhas
doaj  

Factors Associated with Compliance with the Treatment Protocol and Mortality in Adults with Hemophilia

Patient Preference and Adherence, 2020
Beatriz Mac Dowell Soares,1,2 Luiz Alberto Simeoni,2 Karlo Jozefo Quadros de Almeida,1 Jaqueline Lima de Souza,1 Aline Mizusaki Imoto,1,3 Melina Swain Braverman,3 Lucas Barbosa Bezerra,1 Alexandre Jorge Teixeira Ribeiro,1,3 Ana Maria Costa,1 Fábio
Soares BMD, Simeoni LA, de Almeida KJQ, de Souza JL, Imoto AM, Braverman MS, Bezerra LB, Ribeiro AJT, Costa AM, Amorim FF   +9 more
doaj  

Factors associated to patients' noncompliance with hypertension treatment Factores asociados a la no adhesión de los pacientes al tratamiento de hipertensión arterial Fatores associados à não adesão dos pacientes ao tratamento de hipertensão arterial

Revista Latino-Americana de Enfermagem, 2009
The greatest challenge posed by Systemic Hypertension (SH) is related to patients' compliance with treatment. Thus, this study aimed to determine attendance of these patients to medical appointments and the percentage of adherence to medication and non ...
Camila Dosse, Claudia Bernardi Cesarino, José Fernando Vilela Martin, Maria Carolina Andrade Castedo   +3 more
doaj   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Adherence to treatment: what is done in Sweden? Practice, education and research

Pharmacy Practice, 2008
Objective: The objective of this review was to identify the practice, education and research of pharmacists in Sweden in regard to adherence to treatment.Methods: Medline was searched up to the end of February 2008.
Södergård B
doaj  

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source