Results 41 to 50 of about 4,178,246 (299)

Compliance with Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea [PDF]

Sleep Medicine Research, 2020
Obstructive sleep apnea (OSA) is caused by upper airway obstruction during sleep and increases risk for stroke and cardiovascular morbidity. It is also related to excessive daytime sleepiness and cognitive dysfunction in affected adults.
Min Young Seo, Seung Hoon Lee
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Adherence and Wearing Time of Prescribed Footwear among People at Risk of Diabetes-Related Foot Ulcers: Which Measure to Use?

Sensors, 2023
Adherence to prescribed footwear is essential to prevent diabetes-related foot ulcers. The aim was to compare different measures of adherence and wearing time of prescribed footwear with a reference adherence measure, among people with diabetes at high ...
Gustav Jarl, Chantal M. Hulshof, Tessa E. Busch-Westbroek, Sicco A. Bus, Jaap J. van Netten   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Patient self-management in kidney transplantation. definition, measurement, and intervention [PDF]

, 2009
While one-year graft survival rates for deceased donor transplants have soared from about 40% in 1975 to more than 90% in 2005 [1], the long-term perspective has changed very little.
Schäfer-Keller, Petra
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Tradução e validação para o português do Medication Regimen Complexity Index Translation and validation into portuguese Language of the Medication Regimen Complexity Index

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: A complexidade da farmacoterapia consiste de múltiplas características do regime prescrito, incluindo o número de diferentes medicações no esquema, o número de unidades de dosagem por dose, o número total de doses por dia e os cuidados na ...
Ana Carolina Melchiors, Cassyano Januário Correr, Fernando Fernández-Llimos   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effectiveness of post-extraction instruction delivery methods on patients’ understanding and compliance: a randomized controlled trial

BMC Medical Education
Background Video-based educational tools are becoming more commonly used among medical professionals to deliver instructions to patients. However, no studies have assessed patients’ compliance with and understanding of post-operative instructions ...
Abrar K. Demyati, Afnan A. Nassar, Amal Alqahtani, Ghaida Alshareef, Shaima Aljefri, Futoon Yankisar   +5 more
doaj   +1 more source

Self-efficacy, self-esteem and adherence to treatment in people with venous ulcer in primary health care

Bioscience Journal, 2017
To analyze the correlation between self-efficacy, self-esteem and adherence to treatment with the Charing Cross Venous Ulcer Questionnaire in people with Venous Ulcer in Primary Health Care.
Rafaela Araújo Oliveira, Rhayssa de Oliveira e Araújo, Vanessa Gomes da Costa, Lara Laise Alves da Silva, Camila Cintya Fernandes Morais, Sandra Maria da Solidade Gomes Simões de Oliveira Torres, Aline Maino Pergola- Marconato, Quinidia Lúcia Duarte de Almeida Quithé de Vasconcelos, Gilson de Vasconcelos Torres   +8 more
doaj   +1 more source