Results 41 to 50 of about 65,036 (300)

Tradução e validação para o português do Medication Regimen Complexity Index Translation and validation into portuguese Language of the Medication Regimen Complexity Index

Arquivos Brasileiros de Cardiologia, 2007
FUNDAMENTO: A complexidade da farmacoterapia consiste de múltiplas características do regime prescrito, incluindo o número de diferentes medicações no esquema, o número de unidades de dosagem por dose, o número total de doses por dia e os cuidados na ...
Ana Carolina Melchiors, Cassyano Januário Correr, Fernando Fernández-Llimos   +2 more
doaj   +1 more source

Improving compliance behaviour after discharge: the role of a hospital pharmacist [PDF]

, 2002
This thesis demonstrates that compliance is problematic in the elderly population studied and requires intervention if treatment failure is to be avoided.
Robson, Jane
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Self-efficacy, self-esteem and adherence to treatment in people with venous ulcer in primary health care

Bioscience Journal, 2017
To analyze the correlation between self-efficacy, self-esteem and adherence to treatment with the Charing Cross Venous Ulcer Questionnaire in people with Venous Ulcer in Primary Health Care.
Rafaela Araújo Oliveira, Rhayssa de Oliveira e Araújo, Vanessa Gomes da Costa, Lara Laise Alves da Silva, Camila Cintya Fernandes Morais, Sandra Maria da Solidade Gomes Simões de Oliveira Torres, Aline Maino Pergola- Marconato, Quinidia Lúcia Duarte de Almeida Quithé de Vasconcelos, Gilson de Vasconcelos Torres   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effectiveness of post-extraction instruction delivery methods on patients’ understanding and compliance: a randomized controlled trial

BMC Medical Education
Background Video-based educational tools are becoming more commonly used among medical professionals to deliver instructions to patients. However, no studies have assessed patients’ compliance with and understanding of post-operative instructions ...
Abrar K. Demyati, Afnan A. Nassar, Amal Alqahtani, Ghaida Alshareef, Shaima Aljefri, Futoon Yankisar   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The failing diabetic patient in primary care [PDF]

, 2006
Diabetes is a progressive disorder. The majority of people with Type 2 diabetes are likely to require more intensive treatment regimes over time and a substantial proportion have sub-optimal glycaemic control as measured by glycated haemoglobin (HbA1c ...
Jeavons, David Anthony
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source