Results 81 to 90 of about 1,172,159 (295)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Perceptions and Reactions with Regard to Pneumonic Plague

Emerging Infectious Diseases, 2010
We assessed perceptions and likely reactions of 1,005 UK adults to a hypothetical terrorist attack involving pneumonic plague. Likely compliance with official recommendations ranged from good (98% would take antimicrobial drugs) to poor (76% would visit ...
G. James Rubin, Richard Amlôt, M. Brooke Rogers, Ian Hall, Steve Leach, John Simpson, Simon Wessely   +6 more
doaj   +1 more source

Lifting the lid: a clinical audit on commode cleaning [PDF]

, 2010
Many healthcare-associated infections (HCAIs) are preventable by infection control procedures designed to interrupt the transmission of organisms from a source. Commodes are in use constantly throughout healthcare facilities.
Ayliffe GAJ, Biotrace., Centres for Disease Control and Prevention, Cresswell J., Department of Health, Department of Health, Department of Health, Department of Health, Helen Bucior, Higgs J., I nfection Control Nurses Association, Inglis TJJ., Joan Cochrane, LoBiondo-Wood G., National Audit Office, National Clostridium difficile Standards Group, National Institute for Clinical Excellence, National Patient Safety Agency, NHS Estates, Pratt R., Wilson J.   +20 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Nested Markov Compliance Class Model in the Presence of Time-Varying Noncompliance [PDF]

, 2006
We consider a Markov structure for partially unobserved time-varying compliance classes in the Imbens-Rubin (1997) compliance model framework. The context is a longitudinal randomized intervention study where subjects are randomized once at baseline ...
Elliott, Michael R, Lin, Julia Y, TenHave, Thomas R   +2 more
core   +1 more source

A system dynamics-based simulation study for managing clinical governance and pathways in a hospital [PDF]

, 2010
This paper examines the development of clinical pathways in a hospital in Australia based on empirical clinical data of patient episodes. A system dynamics (SD)-based decision support system (DSS) is developed and analyzed for this purpose.
Dangerfield, BC, Maliapen, M
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Addressing High Alcohol Consumption and Alcohol Use Disorders Among Adolescents and Young People in Sub-Saharan Africa: Pathways to Effective Action

Substance Abuse and Rehabilitation
Munanura Turyasiima,1,2 Balbina Gillian Akot,2 Ibrahimu Makongwa,3 Hamdi Mohamed Yusuf,2 Joshua Epuitai4 1Department of Standards, Compliance, Accreditation and Patient Protection (SCAPP), Ministry of Health, Kampala, Uganda; 2Department of Pediatrics ...
Turyasiima M, Akot BG, Makongwa I, Yusuf HM, Epuitai J   +4 more
doaj  

Pengaruh Kunjungan Rumah Oleh Perawat Terhadap Tingkat Kepatuhan Pengobatan Penderita Pneumonia Pada Balita Di Wilayah Kerja Puskesma 2 Baturraden. [PDF]

, 2007
Nurse home visiting program is very important for patient who suffered from pneumonia especially for children under five years old. This program can influence patient compliance during pneumonia treatment.
Istiawan, R. (Rochani), Riyadi, S. (Sugeng), Triasih, F. (Fajar)   +2 more
core