Results 121 to 130 of about 7,319,046 (301)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Development and pilot testing of the Population And ContExt adaption of decision aids (PACE) framework

PEC Innovation
Objective: This study aimed to develop and pilot test a new framework for the adaptation of patient decision aids (PtDAs) using a specific case example of contraceptive method PtDAs for Chinese-speaking migrant women.
Hankiz Dolan, Deborah Bateson, Mu Li, Rachel Thompson, Chun Wah Michael Tam, Carissa Bonner, Lyndal Trevena   +6 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Have a vital end-user been overlooked? Developing a shared decision intervention for patients with potential pancreatic cancer regarding the choice of surgery

PEC Innovation
Objective: To develop a patient decision aid facilitating shared decision making for patients with potential pancreatic cancer deciding about no treatment, surgical or medical treatment.
Kristine Elberg Dengsø, Anne Berg, Carsten Palnæs Hansen, Stefan K. Burgdorf, Paul S. Krohn, Martin Sillesen, Nina Spiegelhauer, Mette Tholstrup Bach, Marianne Melton, Betina Nielsen, Bo Marcel Christensen, Jeanette Finderup, Jens Hillingsø   +12 more
doaj   +1 more source

Family Involvement During Patient Hospitalisation:Developing and Testing a Clinical Decision Aid [PDF]

BACKGROUND: The rising prevalence of multi-morbidity increases treatment complexity and caregiving demands, often necessitating involvement of family members as informal caregivers.
Christensen, Leah Sejrup; id_orcid, Andersen, Mette Hulbæk; id_orcid, Hoffmann, Eva, Brink, Anette   +3 more
core   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Improving sustainability of a patient decision aid for systemic treatment of metastatic colorectal cancer: A qualitative study

PEC Innovation
Objective: To improve sustainability of a patient decision aid for systemic treatment of metastatic colorectal cancer, we evaluated real-world experiences and identified ways to optimize decision aid content and future implementation.
Sietske C.M.W. van Nassau, Helene R. Voogdt-Pruis, Vincent M.W. de Jong, Hans-Martin Otten, Liselot B. Valkenburg-van Iersel, Bas J. Swarte, Tineke E. Buffart, Hans J. Pruijt, Leonie J. Mekenkamp, Miriam Koopman, Anne M. May   +10 more
doaj   +1 more source