Results 111 to 120 of about 7,319,046 (301)

Efficacy and safety of the Patient Empowerment through Predictive Personalised Decision Support (PEPPER) system: an open-label randomised controlled trial [Pòster]

, 2020
Pòster de congrés presentat a: ATTD 2020 - 13th International Conference on Advanced Technologies & Treatments for Diabetes”, celebrat a Madrid del 19 al 22 de febrer de 2020PEPPER (Patient Empowerment through Predictive PERsonalised decision support) is
Martin, Clare, Fernández-Balsells, Mercè, Avari, Parizad, López Ibáñez, Beatriz, Reddy, Monika, Fernández-Real Lemos, José Manuel, Nita, Lucian, Herrero i Viñas, Pau, Massana i Raurich, Joaquim, Wos, Marzena, Thomas, Maria, Jugnee, Narvada, Oliver, Nick, Leal Moncada, Yenny Teresa   +13 more
core   +1 more source

Development of a web-based patient decision aid for initiating disease modifying anti-rheumatic drugs using user-centred design methods

BMC Medical Informatics and Decision Making, 2017
Background A main element of patient-centred care, Patient Decision Aids (PtDAs) facilitate shared decision-making (SDM). A recent update of the International Patient Decision Aids Standards (IPDAS) emphasised patient involvement during PtDA development,
Ingrid Nota, Constance H. C. Drossaert, Heleen C. Melissant, Erik Taal, Harald E. Vonkeman, Cees J. Haagsma, Mart A. F. J. van de Laar   +6 more
doaj   +1 more source

Iterative modification and finalization of a patient decision-aid for immunosuppressive medication treatment decision-making in systemic lupus erythematosus by a racially diverse patient group

Objective: To describe the patient-feedback process for iterative modification and finalization of the systemic lupus erythematosus (SLE) decision-aid.
Green, Candace, Gontarz, Shelby, Riofrio, Maria, Singh, Jasvinder A   +3 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The UPFRONT project: tailored implementation and evaluation of a patient decision aid to support shared decision-making about management of symptomatic uterine fibroids

Implementation Science
Objective To evaluate implementation of a patient decision aid for symptomatic uterine fibroid management to improve shared decision-making at five clinical settings across the United States.
Rachel C. Forcino, Marie-Anne Durand, Danielle Schubbe, Jaclyn Engel, Erika Banks, Shannon K. Laughlin-Tommaso, Tina Foster, Tessa Madden, Raymond M. Anchan, Mary Politi, Anne Lindholm, Rossella M. Gargiulo, Maya Seshan, Marisa Tomaino, Jingyi Zhang, Stephanie C. Acquilano, Sade Akinfe, Anupam Sharma, Johanna W. M. Aarts, Glyn Elwyn   +19 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Development of a Patient Decision Aid for Patients with Rectal Cancer

, 2011
Context: Rectal cancer treatment decisions involve tradeoffs between outcomes like living with a permanent stoma versus long-term bowel dysfunction. The needs of rectal cancer patients and practitioners to partake in shared decision making are unknown.
Scheer, Adena Sarah
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Evidence-based patient choice: a prostate cancer decision aid in plain language

BMC Medical Informatics and Decision Making, 2005
Background Decision aids (DA) to assist patients in evaluating treatment options and sharing in decision making have proliferated in recent years. Most require high literacy and do not use plain language principles.
Ohene-Frempong Janet, Dunn Rodney L, Wei John T, Fagerlin Angela, Stableford Sue, Holmes-Rovner Margaret, Kelly-Blake Karen, Rovner David R   +7 more
doaj   +1 more source