Results 91 to 100 of about 6,814,812 (297)

Research progress on application of patient decision aid in orthopedic

Huli yanjiu, 2021
This paper introduced content，form，scope of application，significance and influencing factors of patient decision aid in orthopedic，in order to provide reference for carrying out related research and improving quality of treatment decision⁃making for ...
YAO Minghe, TURSUN Nafisa, ZHANG Yanlong, LI Jing, QING Ping   +4 more
doaj  

The Effect of Patient Narratives on Information Search in a Web-Based Breast Cancer Decision Aid: An Eye-Tracking Study

Journal of Medical Internet Research, 2013
BackgroundPrevious research has examined the impact of patient narratives on treatment choices, but to our knowledge, no study has examined the effect of narratives on information search.
Shaffer, Victoria A, Owens, Justin, Zikmund-Fisher, Brian J   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Decision aids in patient-physician communication for supporting shared decision making and patient satisfaction: an experimental study

, 2022
The aim of this study was to explore the effect of the use and style of decision aids on shared decision making and patient satisfaction in patient-physician communication in the context of Generalized Anxiety Disorder (GAD). An experimental study design
Salous, Bushra
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cultural adaptation of a patient decision-aid for insulin therapy

BMJ Open, 2020
Introduction Patient decision-aids (PDAs) support patients in selecting evidence-based treatment options. PDA is useful only if the user understands the content to make personalised decisions. Cultural adaptation is a process of adjusting health messages
Josip Car, John Furler, Ngiap Chuan Tan, Agnes Koong Ying Leng, Ian Phoon Kwong Yun, Sinead Wang Zhen, Muthulakshmi Paulpandi, Yew Kong Lee, Chirk Jenn Ng   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A personalized decision aid for prostate cancer shared decision making

, 2021
A shared decision-making model is preferred for engaging prostate cancer patients in treatment decisions. However, the process of assessing an individual's preferences and values is challenging and not formalized.
Morton, Gerard, Buyyounouski, Mark K, Scheinker, David, Bagshaw, Hilary P, Pollack, Alan, Stoyanova, Radka, Heidari, Nastaran, Horwitz, Eric, Kishan, Amar U, Martinez, Alejandro   +9 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source