Results 101 to 110 of about 393,515 (298)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A stochastic multi-scale model of HIV-1 transmission for decision-making: application to a MSM population. [PDF]

, 2013
BackgroundIn the absence of an effective vaccine against HIV-1, the scientific community is presented with the challenge of developing alternative methods to curb its spread.
Cumberland, William G, Yang, Otto O, Yeghiazarian, Lilit   +2 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The employment of Patient-Reported Outcome Measures to communicate the likely benefits of surgery

Patient Related Outcome Measures, 2018
Norman Briffa1,2 1Sheffield Teaching Hospitals, NHS Trust, Sheffield, UK; 2University of Sheffield, Sheffield, UK Abstract: Decision aids as part of shared care are underutilized in surgery.
Briffa N
doaj  

New Diagnostics for Tuberculosis: Fulfilling Patient Needs First [PDF]

, 2010
An effective tuberculosis (TB) control programme requires early diagnosis and immediate initiation of treatment. Any delays in diagnosing TB not only impair a patient's prognosis, but also increase the risks of transmitting the disease within the ...
Lemaire, J-F, Casenghi, M
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interpretation of the "Standards for universal reporting of patient decision aid evaluation studies(SUNDAE)"

Huli yanjiu
To improve the quality and enhance the transparency and completeness of reporting for evaluation studies of patient decision aids,the International Patient Decision Aid Standards(IPDAS) Collaboration Group published the SUNDAE(Standards for universal ...
QIU Yu, HOU Dan, WANG Jianing, LU Xiaoqian   +3 more
doaj  

Are patient decision aids effective? Insight from revisiting the debate between correspondence and coherence theories of judgment

Judgment and Decision Making, 2009
Research endeavors to determine the effectiveness of patient decision aids (PtDAs) have yielded mixed results. The conflicting evaluations are largely due to the different metrics used to assess the validity of judgments made using PtDAs.
Victoria A. Shaffer, Lukas Hulsey, Philip T. Dunwoody, Robin Hogarth   +3 more
doaj   +1 more source

Key Topics on End-of-Life Care for African Americans [PDF]

, 2006
Racial classifications of human populations are politically and socially determined. There is no biological or genetic basis for these racial classifications. Health behaviors may be influenced by culture and poverty.
Bernice Harper, Bethsheba Johnson, Camilla Hudson, Diane Deese, Fay Burrs, Gloria Ramsey, Gwendolyn London, Harold Freeman, Jeremiah Wright, Jr., Joseph Dancy, Jr., Karla Holloway, Kelvin Calloway, LaVera Crawley, Michelle Grant Ervin, Myra Christopher, Paul Smith, Pernessa Seele, Richard Payne, Robert Washington, Rosalyn Priester, Sharon R. Latson, Skaykh Ibrahim Abdul-Malik, William Johnson, Willie Davis   +23 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source