Results 121 to 130 of about 114,366 (208)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improving patient experience through co-designed patient decision aids in glaucoma. [PDF]

Eye (Lond)
Henein C, Tan JK, Kilduff C, Mathew RG.
europepmc   +1 more source

Co-creating a suite of patient decision aids for parents of an infant or young child with differences of sex development: A methods roadmap. [PDF]

Front Urol, 2023
Lightfoot S, Carley M, Brinkman W, Gardner MD, Gruppen LD, Liang N, Pinkelman K, Speiser PW, Suorsa-Johnson KI, VanderBrink B, Wisniewski J, Sandberg DE, Stacey D.   +12 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Sex and gender reporting and differences in trials evaluating patient decision aids: a secondary analysis of systematic review with meta-analysis. [PDF]

BMJ Open
Stacey D, Légaré F, Lewis KB, Smith M, Carley ME, Barry MJ, Bennett C, Bravo P, Steffensen KD, Finderup J, Gendler Y, Gogovor A, Gunderson J, Kelly SE, Pacheco-Brousseau L, Trenaman L, Trevena L, Volk RJ, Graham ID.   +18 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Patient Decision Aids into Routine Orthopedic Care: Results from an Implementation Study at 12 Sites. [PDF]

Med Decis Making
Sepucha K, Vo H, Marques F, Valentine KD, Abdeen A, Bedair H, Chen AF, Eisler J, Freccero D, Jayakumar P, Kropfl E, Paul K, Ricciardi B, Vigil D, Wexler R, Williamson T, Yates A, Cha T.   +17 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effectiveness of patient decision aids for cardiovascular decisions: systematic review with sex/gender-based analysis. [PDF]

Eur J Cardiovasc Nurs
Lewis KB, Graham ID, Lauck SB, Carley ME, Bennett C, Gessese S, Stacey D.   +6 more
europepmc   +1 more source

Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial. [PDF]

Korean J Anesthesiol, 2023
Wang LK, Lin YT, Chen JT, Lan W, Hung KC, Chen JY, Liu KJ, Yen YC, Chou YY, Cherng YG, Tam KW.   +10 more
europepmc   +1 more source