Results 131 to 140 of about 114,366 (208)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Clinicians' perspectives on the implementation of patient decision aids in the emergency department: A qualitative interview study. [PDF]

J Am Coll Emerg Physicians Open, 2022
Billah T, Gordon L, Schoenfeld EM, Chang BP, Hess EP, Probst MA.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Patient Decision Aids for Pelvic Floor Surgery and Impact on Decisional Conflict. [PDF]

BJOG
Bugeja R, Athey R, Jha S.
europepmc   +1 more source

A scattered landscape: assessment of the evidence base for 71 patient decision aids developed in a hospital setting. [PDF]

BMC Med Inform Decis Mak, 2022
Danner M, Debrouwere M, Rummer A, Wehkamp K, Rüffer JU, Geiger F, Wolff R, Weik K, Scheibler F.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The quality of patient decision aids for lung cancer screening: Results from an environmental scan. [PDF]

Cancer
Volk RJ, Lettieri JS, Leal VB, Duhon GF, Maki KG, Bernal Brietzke MP, Tan NQP, Douglas EE, Coles S, Ebell MH, Mejia MC, Kazerooni EA, Rosenthal L, Smith RA.   +13 more
europepmc   +1 more source

Cardiology providers' recommendations for treatments and use of patient decision aids for multivessel coronary artery disease. [PDF]

BMC Cardiovasc Disord, 2021
Nichols EL, Elwyn G, DiScipio A, Sidhu MS, O'Malley AJ, Matlock DD, Alam S, Ross CS, Coylewright M, Malenka DJ, Brown JR.   +10 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Defining the strategies to advance health-literacy-friendly patient decision aids based on the ICA-NRM approach. [PDF]

BMC Health Serv Res
Yu SF, Kuo PJ, Lin HC, Yu HT.
europepmc   +1 more source