Results 141 to 150 of about 114,366 (208)

Processes for evidence summarization for patient decision aids: A Delphi consensus study. [PDF]

Health Expect, 2021
Scalia P, Saunders CH, Dannenberg M, Mc Giguere A, Alper BS, Hoffmann T, Perestelo-Perez L, Durand MA, Elwyn G.   +8 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Effects of patient decision aids used pre-consult or in-consult on patient-clinician communication - secondary analysis of a systematic review with meta-analysis. [PDF]

BMC Med Inform Decis Mak
Knudsen BM, Søndergaard SR, Carley M, Steffensen KD, Stacey D.   +4 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Online training for Japanese healthcare professionals in the development and use of patient decision aids to facilitate shared decision-making: An acceptability study. [PDF]

PEC Innov
Osaka W, Aoki Y, Yonekura Y, Danya H, Nakayama K.   +4 more
europepmc   +1 more source

Potential impact of encounter patient decision aids on the patient-clinician dialogue: a qualitative study on Dutch and American medical specialists' experiences. [PDF]

BMJ Open, 2022
Rake EA, Dreesens D, Venhorst K, Meinders MJ, Geltink T, Wolswinkel JT, Dannenberg M, Kremer JAM, Elwyn G, Aarts JWM.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Exploring Values Clarification and Health-Literate Design in Patient Decision Aids: A Qualitative Interview Study. [PDF]

Med Decis Making
Ayre J, Jenkins H, Kumarage R, McCaffery KJ, Maher CG, Hancock MJ.   +5 more
europepmc   +1 more source

What can we learn from rapidly developed patient decision aids produced during the covid-19 pandemic?

BMJ, 2022
Barry MJ, Härter M, Househ M, Steffensen KD, Stacey D.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source