Results 171 to 180 of about 393,515 (298)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Sex and gender reporting and differences in trials evaluating patient decision aids: a secondary analysis of systematic review with meta-analysis. [PDF]

BMJ Open
Stacey D, Légaré F, Lewis KB, Smith M, Carley ME, Barry MJ, Bennett C, Bravo P, Steffensen KD, Finderup J, Gendler Y, Gogovor A, Gunderson J, Kelly SE, Pacheco-Brousseau L, Trenaman L, Trevena L, Volk RJ, Graham ID.   +18 more
europepmc   +1 more source

Systematic Development of Patient Decision Aids: An Update from the IPDAS Collaboration. [PDF]

Med Decis Making, 2021
Witteman HO, Maki KG, Vaisson G, Finderup J, Lewis KB, Dahl Steffensen K, Beaudoin C, Comeau S, Volk RJ.   +8 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Improving patient experience through co-designed patient decision aids in glaucoma. [PDF]

Eye (Lond)
Henein C, Tan JK, Kilduff C, Mathew RG.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Patient Decision Aids into Routine Orthopedic Care: Results from an Implementation Study at 12 Sites. [PDF]

Med Decis Making
Sepucha K, Vo H, Marques F, Valentine KD, Abdeen A, Bedair H, Chen AF, Eisler J, Freccero D, Jayakumar P, Kropfl E, Paul K, Ricciardi B, Vigil D, Wexler R, Williamson T, Yates A, Cha T.   +17 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effectiveness of patient decision aids for cardiovascular decisions: systematic review with sex/gender-based analysis. [PDF]

Eur J Cardiovasc Nurs
Lewis KB, Graham ID, Lauck SB, Carley ME, Bennett C, Gessese S, Stacey D.   +6 more
europepmc   +1 more source

Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial. [PDF]

Korean J Anesthesiol, 2023
Wang LK, Lin YT, Chen JT, Lan W, Hung KC, Chen JY, Liu KJ, Yen YC, Chou YY, Cherng YG, Tam KW.   +10 more
europepmc   +1 more source