Results 181 to 190 of about 393,515 (298)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Clinicians' perspectives on the implementation of patient decision aids in the emergency department: A qualitative interview study. [PDF]

J Am Coll Emerg Physicians Open, 2022
Billah T, Gordon L, Schoenfeld EM, Chang BP, Hess EP, Probst MA.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Patient Decision Aids for Pelvic Floor Surgery and Impact on Decisional Conflict. [PDF]

BJOG
Bugeja R, Athey R, Jha S.
europepmc   +1 more source

A scattered landscape: assessment of the evidence base for 71 patient decision aids developed in a hospital setting. [PDF]

BMC Med Inform Decis Mak, 2022
Danner M, Debrouwere M, Rummer A, Wehkamp K, Rüffer JU, Geiger F, Wolff R, Weik K, Scheibler F.   +8 more
europepmc   +1 more source

International Patient Decision Aid Standards (IPDAS): beyond decision aids to usual design of patient education materials [PDF]

Health Expectations, 2007
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The quality of patient decision aids for lung cancer screening: Results from an environmental scan. [PDF]

Cancer
Volk RJ, Lettieri JS, Leal VB, Duhon GF, Maki KG, Bernal Brietzke MP, Tan NQP, Douglas EE, Coles S, Ebell MH, Mejia MC, Kazerooni EA, Rosenthal L, Smith RA.   +13 more
europepmc   +1 more source

Cardiology providers' recommendations for treatments and use of patient decision aids for multivessel coronary artery disease. [PDF]

BMC Cardiovasc Disord, 2021
Nichols EL, Elwyn G, DiScipio A, Sidhu MS, O'Malley AJ, Matlock DD, Alam S, Ross CS, Coylewright M, Malenka DJ, Brown JR.   +10 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source