Results 41 to 50 of about 1,027,659 (352)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bridges and Barriers: Patients\u27 Perceptions of the Discharge Process Including Multidisciplinary Rounds on a Trauma Unit [PDF]

open access: yes, 2015
Discharge planning is a complex process and ideally begins early in the patient stay. Despite evidence about the importance of discharge readiness, there is limited literature about the patient\u27s view during this transition. The goal of this study was
Johnson, Grace   +4 more
core   +1 more source

Disposition and Success of Patients Following Discharge in the Acute Setting

open access: yes, 2017
: Background & Purpose: Many patients are seen in the hospital by physical therapists who also help decide where the patient will go after discharge (e.g., home, rehab hospital, skilled nursing facility) with the goal being the safest and best quality of
Cortney, Ciera   +2 more
core   +1 more source

A qualitative study exploring hospital-based team dynamics in discharge planning for patients experiencing delayed care transitions in Ontario, Canada

open access: yesBMC Health Services Research, 2022
Background In attempt to improve continuity of patient care and reduce length of stay, hospitals have placed an increased focus on reducing delayed discharges through discharge planning.
Lauren Cadel   +4 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Patients’ Perceptions of Relative Importance of Discharge Elements (PRIDE) Study [PDF]

open access: yes, 2019
Background: Almost 20% of patients experience potentially preventable adverse events within 30 days of hospital discharge (Forster, et al, 2003). The Agency for Healthcare Research and Quality recommends structured and patient-centered discharge ...
Kurbanova, Nargiza
core   +1 more source

Littoral Rights Under the Takings Doctrine: The Clash Between the Ius Naturale And Stop The Beach Renourishment [PDF]

open access: yes, 2011
Background. Organizing and performing patient transfers in the continuum of care is part of the work of nurses and other staff of a multiprofessional healthcare team.
Britt Bäckström, Marie Häggström
core   +4 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

AVALIAÇÃO DO SCORE SOFA DE PACIENTES COVID INTERNADOS EM UNIDADE DE TERAPIA INTENSIVA FRENTE AO DESFECHO ALTA OU ÓBITO

open access: yesSağlık Akademisi Kastamonu, 2022
Introdução: A gravidade do Coronavírus é causada por uma tempestade de citocinas que causam alterações imunopatológicas tanto nos pulmões como nos demais órgãos causando diversos agravos orgânicos no quadro de pacientes Covid positivos.
Danielle Bordin   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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