Results 61 to 70 of about 19,050,112 (390)

Applying Quality Improvement methods to address gaps in medicines reconciliation at transfers of care from an acute UK hospital [PDF]

, 2016
© Published by the BMJ Publishing Group Limited.Objectives Reliable reconciliation of medicines at admission and discharge from hospital is key to reducing unintentional prescribing discrepancies at transitions of healthcare.
Bell, D, Kuo, S, Marvin, V, Poots, A, Vaughan, L, Woodcock, T   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experiences of Home Care Team Members and Family Caregivers in Addressing the Care Needs of Patients with Severe Traumatic Brain Injury During the Post-discharge Period

Iranian Journal of Nursing and Midwifery Research
Background: Providing care for unconscious patients with severe brain injuries at home can be challenging. One of the main difficulties is identifying and addressing their specific care needs.
Shahla Mohamadirizi, Alireza Irajpour, Amir Mahaabadi, Bahram Aminmansour, Nasrolah Alimohammadi   +4 more
doaj   +1 more source

Repeat prescribing of medications: a system-centred risk management model for primary care organisations [PDF]

, 2017
Rationale, aims and objectives: Reducing preventable harm from repeat medication prescriptions is a patient safety priority worldwide. In the United Kingdom, repeat prescriptions items issued has doubled in the last 20 years from 5.8 to 13.3 items ...
Bartlett, Stephen, Bowie, Paul, Dinwoodie, Mark, Man, Shu Ling, Price, Julie, Taylor, Kate   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discharge Follow-Up of Patients in Primary Care Does Not Meet Their Care Needs: Results of a Longitudinal Multicentre Study

Nursing Reports
Adequate coordination between healthcare levels has been proven to improve clinical indicators, care costs, and user satisfaction. This is more relevant to complex or vulnerable patients, who often require increased care.
Noelia López-Luis, Cristobalina Rodríguez-Álvarez, Angeles Arias, Armando Aguirre-Jaime   +3 more
doaj   +1 more source

Analysis of factors affecting discharge with the personal consent of hospitalized patients: A cross‐sectional study

Health Science Reports, 2023
Background and Aims Discharge by personal satisfaction is a condition in which the patient leaves the hospital before completing the care period against medical advice.
Zahra Babaei, Masoumeh Alizadeh, Soodeh Shahsawari, Azar Jihoni‐Kalhori, Ramin Cheraghbeigi, Rahman Sotoudeh, Ali Mohammadi   +6 more
doaj   +1 more source

Adherence to UK national guidance for discharge information: an audit in primary care [PDF]

, 2014
Aims: Poor communication of clinical information between healthcare settings is associated with patient harm. In 2008, the UK National Prescribing Centre (NPC) issued guidance regarding the minimum information to be communicated upon hospital discharge ...
Bhattacharya, Debi, Hammad, Eman A., Nunney, Ian, Walton, Christine, Wright, David John   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

What makes a “successful” or “unsuccessful” discharge letter? Hospital clinician and General Practitioner assessments of the quality of discharge letters

BMC Health Services Research, 2021
Background Sharing information about hospital care with primary care in the form of a discharge summary is essential to patient safety. In the United Kingdom, although discharge summary targets on timeliness have been achieved, the quality of discharge ...
Katharine Weetman, Rachel Spencer, Jeremy Dale, Emma Scott, Stephanie Schnurr   +4 more
doaj   +1 more source