Results 51 to 60 of about 4,076,980 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experiences of Home Care Team Members and Family Caregivers in Addressing the Care Needs of Patients with Severe Traumatic Brain Injury During the Post-discharge Period

Iranian Journal of Nursing and Midwifery Research
Background: Providing care for unconscious patients with severe brain injuries at home can be challenging. One of the main difficulties is identifying and addressing their specific care needs.
Shahla Mohamadirizi, Alireza Irajpour, Amir Mahaabadi, Bahram Aminmansour, Nasrolah Alimohammadi   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Discharge Follow-Up of Patients in Primary Care Does Not Meet Their Care Needs: Results of a Longitudinal Multicentre Study

Nursing Reports
Adequate coordination between healthcare levels has been proven to improve clinical indicators, care costs, and user satisfaction. This is more relevant to complex or vulnerable patients, who often require increased care.
Noelia López-Luis, Cristobalina Rodríguez-Álvarez, Angeles Arias, Armando Aguirre-Jaime   +3 more
doaj   +1 more source

A Clinical Audit of Discharge Summaries: Conformity to Set Guidelines in the Department of Psychiatry and Mental Health at Mmuhimbili National Hospital Dar es Salaam Tanzania. [PDF]

, 2012
Patients‟ records are the most basic clinical tools that are required in every consultation. Discharge summary as a document collect patient‟s information about inpatients care. The primary function is to support continuity of care as the patient returns
Mfangavo, Heriel H., Mfangavo, H.H.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Analysis of factors affecting discharge with the personal consent of hospitalized patients: A cross‐sectional study

Health Science Reports, 2023
Background and Aims Discharge by personal satisfaction is a condition in which the patient leaves the hospital before completing the care period against medical advice.
Zahra Babaei, Masoumeh Alizadeh, Soodeh Shahsawari, Azar Jihoni‐Kalhori, Ramin Cheraghbeigi, Rahman Sotoudeh, Ali Mohammadi   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Nurses’ functional status assessments using the International Classification of Functioning, Disability, and Health across hospital types in Japan: A cross-sectional study

Belitung Nursing Journal
Background: In Japan, patients receiving treatment in advanced acute care hospitals often cannot return home immediately and require ongoing hospitalization.
Kanako Yamamoto
doaj   +1 more source

What makes a “successful” or “unsuccessful” discharge letter? Hospital clinician and General Practitioner assessments of the quality of discharge letters

BMC Health Services Research, 2021
Background Sharing information about hospital care with primary care in the form of a discharge summary is essential to patient safety. In the United Kingdom, although discharge summary targets on timeliness have been achieved, the quality of discharge ...
Katharine Weetman, Rachel Spencer, Jeremy Dale, Emma Scott, Stephanie Schnurr   +4 more
doaj   +1 more source