Results 111 to 120 of about 521,278 (295)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Improving Patient Education: Effective Ways to Develop and Deliver Information about Health-Related Behaviors

open access: yesMedEdPORTAL, 2015
This educational tool kit has been developed for health professional learners to provide instruction on patient education practices in health care as well as to engage learners in designing patient education tools.
Christopher AhnAllen, DeAnna Mori
doaj   +1 more source

Surgical patient education: Turkish nursing students experiences

open access: yes, 2007
Patient education has been widely used by medical schools and schools of nursing as a method for evaluating clinical performance. Training of patients provides a viable method for teaching and evaluating nurse practitioner students as they progress ...
Kaymakçi S., Orgun F., Yavuz M.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Development and Evaluation of Patient Education Materials

open access: yes, 1988
It has often been thought that clients do not follow through with medical recommendations because they do not have the motivation. It may not be a question of motivation but rather a question of comprehension.
Karatsanos, Mary H.
core  

The clinical effectiveness of diabetes education models for Type 2 diabetes: a systematic review

open access: yes, 2008
Objective: To examine the clinical effectiveness of patient education models for adults with Type 2 diabetes.Data sources: Electronic databases were searched from 2002 to January 2007.Review methods: A systematic review of the literature on educational ...
Frampton, G.K.   +5 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

How readable are Australian multilingual diabetes patient education materials? An evaluation of national English-language source texts

open access: yes, 2020
Objective: Multilingual patient education materials (PEMs) in Australia are normally prepared initially in English (source text) and then translated into other languages.
Danielle M Muscat   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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