Results 101 to 110 of about 521,278 (295)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Patient education materials: improving readability to advance health equity

Journal of Perinatal Medicine
To assess the readability of American College of Obstetricians and Gynecologists (ACOG) patient education pamphlets and evaluate changes over 25 years to determine their role as a social determinant of health affecting maternal health disparities.
Grünebaum Amos, Pollet Susan L., McLeod-Sordjan Renee, Bachman Gloria, Chervenak Frank A.   +4 more
doaj   +1 more source

Patient understanding of pharmacogenomic test results in clinical care

, 2023
Objective: Previous research has not objectively assessed patients' comprehension of their pharmacogenomic test results. In this study we assessed understanding of patients who had undergone cytochrome P450 2C19 (CYP2C19) pharmacogenomic testing ...
Shugg, Tyler A., Abigail Garcia, Skaar, Todd C., Schmidt, Karen K., Olivera, Jesus, Colin M.E. Halverson, Todd C. Skaar, Garcia, Abigail, Tyler A. Shugg, Karen K. Schmidt, Schwartz, Peter H., Peter H. Schwartz, Halverson, Colin M. E., Tom A. Doyle, Jesus Olivera, Doyle, Tom A.   +15 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A Layered Approach to Understanding Your Patient: A Tool for Patient Education

MedEdPORTAL, 2013
Patient education encompasses more than just telling a patient to read materials; it is a process of working with a patient to promote behavioral change.
Jill Stefaniak
doaj   +1 more source

An Analysis of Publicly Available Health Education Materials Designed for Migrant Farm Workers

, 2023
BACKGROUND: In the United States, there are more than 3 million migrant or seasonal farm workers each year. The lack of legal protections, low pay, and often-dangerous work conditions lead to serious health inequities for farmworkers and their families.
Wright, Michael Z, NC DOCKS at East Carolina University   +1 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Helping Patients Navigate the Emergency Department: Assessing the Utility of a Poster Illustrating the Patient Journey

Patients often have limited understanding of the emergency department (ED) care process, which can increase anxiety, frustration, and confusion. This study implemented and assessed the usefulness of a poster explaining the ED care process.
Krebs, Lynette D, Ospina, Maria B, Holroyd, Brian R, Rowe, Brian H, Villa-Roel, Cristina   +4 more
core   +1 more source

Readability, Content, and Quality Assessment of Web-Based Patient Education Materials Addressing Neuraxial Labor Analgesia

, 2015
BACKGROUND: Studies in a variety of disciplines have shown that the readability of Web-based patient education materials is above that of the sixth grade reading level recommended by the U.S. Department of Health and Human Services. The aim of this study
Patel, Samir K., Grobman, William A., Goucher, Haley, Gordon, Elisa J., Wong, Cynthia A., Toledo, Paloma   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source