Results 131 to 140 of about 23,797,950 (349)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The patient patient: The importance of knowing your navigator

, 2015
In Ontario, Diagnostic Assessment Programs (DAPs) have been implemented to improve the quality of care patients receive during the diagnostic phase of the cancer journey.
Kaan, Melissa, MBA, Holloway, Claire MB, MD PhD FRCSC, Gilbert, Julie E, PhD, Klonikowski, Eric, Wheeler, Sarah M, PhD   +4 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Challenges of Inclusion: A Population‐Based Interview Study of Long Covid

Health Expectations
Introduction People with long Covid report a wide range of symptoms and inconsistent responses when seeking clinical diagnosis and support. Much of the qualitative research on long Covid has been based on people attending specialist clinical services or ...
Emily Cooper, Adam Lound, Kathryn Jones, Jane Bruton, Sophie Day, Christina J. Atchison, Caroline Eccles, Alex Piper, Graham S. Cooke, Marc Chadeau‐Hyam, Paul Elliott, Helen Ward   +11 more
doaj   +1 more source

Does Patient Experience Change with Age? Exploring Associations Between Patient Experience, Gender and Age

Patient experience measurement is important for healthcare organizations to support the provision of high-quality care. Although previous research suggests age and gender may influence patient experiences, a thorough analysis of these associations ...
Adams, Corey, Sharma, Anurag, Walsan, Ramya, Walpola, Ramesh, Schembri, Anthony, Harrison, Reema   +5 more
core   +1 more source

Patient‐reported outcomes use during orthopaedic surgery clinic visits improves the patient experience

Musculoskeletal Care, 2019
OBJECTIVES The Patient-Reported Outcomes Measurement Information System (PROMIS) is growing in popularity as healthcare shifts towards a value-based system. However, it remains unclear if PROMIS use improves the patient experience. The aim of the present
David N. Bernstein, Kathleen Fear, A. Mesfin, W. Hammert, David J. Mitten, P. Rubery, J. Baumhauer   +6 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

"Why should anyone want to make things better for me particularly?" : A qualitative exploration of Care Opinion and NHS care improvements Patient Experience Journal

Our thanks go to our stakeholder group and CareOpinion for their support.Peer ...
Campbell, Marion K., Campbell, Marion, Locock, Louise, Berry, Emma, Skea, Zoe   +4 more
core   +1 more source

Beneath the surface of talking about physicians: A statistical model of language for patient experience comments

, 2019
This study applies natural language processing (NLP) techniques to patient experience comments. Our goal was to examine the language describing care experiences with two groups of physicians: those with scores in the top 100 and those with scores in the ...
Guney, Senem, PhD, CPXP, Turpen, Taylor, Matthews, Lea, MD   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source