Results 61 to 70 of about 315,014 (266)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Animal-derived ingredients in medicines: a framework for ethical prescribing practices

Frontiers in Pharmacology
An increasing number of patients want to avoid animal-derived ingredients in medications due to ethical, religious, or cultural beliefs, yet transparency about these ingredients remains limited.
Hamdi Lababidi, Christopher Bobier, Daniel Rodger   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Patient involvement in treatment decisions is associated with increased therapy satisfaction in Hidradenitis suppurativa

Frontiers in Medicine
BackgroundHidradenitis suppurativa (HS) is a painful and disfiguring chronic inflammatory skin disease. Despite many efforts over the past decade to improve the care of patients with HS, their satisfaction with medical care remains limited.AimThe aim of ...
Giorgia Cugno, Giorgia Cugno, Giorgia Cugno, Sylke Schneider-Burrus, Sylke Schneider-Burrus, Georgios Kokolakis, Dagmar Wilsmann-Theis, Katharina Assaf, Rotraut Moessner, Christian Kromer, Falk G. Bechara, Nessr Abu Rached, Wiebke K. Peitsch, Lisa C. Schneider, Andreas Happ, Valentina Siddi, Diana Kubitzki, Durdana Groß, Markus Friedrich, Staffan Vandersee, Khusru Asadullah, Robert Sabat, Kerstin Wolk   +22 more
doaj   +1 more source

Cyberchondria: Implications of online behavior and health anxiety as determinants

Archives of Medicine and Health Sciences, 2019
Background: Cyberchondria is excessive worrying about one's health that develops following internet search for medical and health information. Aim: This study investigates how the development of cyberchondria relates to characteristics of the person ...
Denelle Mohammed, Sara Wilcox, Camille Renee, Christine Janke, Niki Jarrett, Anjelika Evangelopoulos, Chasity Serrano, Nazmin Tabassum, Natashia Turner, Melody Theodore, Aleksandar Dusic, Rana Zeine   +11 more
doaj   +1 more source

Treatment Preferences in Patients With Hypothyroidism

The Journal of Clinical Endocrinology & Metabolism
Abstract Context Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4–treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3) or with desiccated thyroid extract (DTE).
Fabyan Esberard de Lima Beltrão, Giulia Carvalhal, Daniele Carvalhal de Almeida Beltrão, Fabricia Elizabeth de Lima Beltrão, Miriam O Ribeiro, Matthew D Ettleson, Helton Estrela Ramos, Antonio C Bianco   +7 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source