Results 71 to 80 of about 3,742,781 (262)

A patient and community-centered approach selecting endpoints for a randomized trial of a novel advance care planning tool

Patient Preference and Adherence, 2018
John FP Bridges,1,2 Norah L Crossnohere,2 Anne L Schuster,1 Judith A Miller,3 Carolyn Pastorini,3,† Rebecca A Aslakson2,4,5 1Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD ...
Bridges JFP, Crossnohere NL, Schuster AL, Miller JA, Pastorini C, Aslakson RA   +5 more
doaj  

Evaluation of Patient Satisfaction, Preference and Side Effects after Annual Zoledronic Acid Infusion in Patients with Osteoporosis

Türk Osteoporoz Dergisi, 2017
Objective: In this study it was aimed to evaluate the patient satisfaction, therapy preference and side-effect profile in patients who receive annual zoledronic acid (ZA) infusion.
Banu Dilek, Ebru Şahin, Didem Erdem, Deniz Bulut, Selmin Gülbahar   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient-initiated discharge from emergency departments and the related factors in Jiroft, South of Iran [PDF]

Journal of Holistic Nursing and Midwifery
Introduction: Patients’ self-discharge may indicate dissatisfaction with healthcare services. In some cases, it can lead to re-hospitalization or even the death of the patient.
Shima Groohi-sardou, Akbar Anaei Goudari, Vahid Rahmanian, Reza Faryabi, Najmeh Ghasemian, Ehsan Goroei Sardou, Salman Daneshi   +6 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

US Retina Specialists’ Preferences for Geographic Atrophy Treatment

Clinical Ophthalmology
Karl Csaky,1 Anthony M Pepio,2 Caitlin Thomas,3 Bennett Levitan,4 Seema Garg,5 Nguyet Tran,4 Ilan Irony,6 Nicolas Krucien,3 Anastasia Doldos,3 Jennifer A Whitty3 1Ophthalmology Department, Retina Foundation of the Southwest, Dallas, TX, USA; 2Research ...
Csaky K, Pepio AM, Thomas C, Levitan B, Garg S, Tran N, Irony I, Krucien N, Doldos A, Whitty JA   +9 more
doaj  

Acceptance and Preference of Computed Tomographic Colonography and Colonoscopy: Results of a Nationwide Multicenter Comparative Questionnaire Survey in Japan

Journal of the Anus, Rectum and Colon
Objectives: To investigate patient acceptance and preference for computed tomographic colonography (CTC) over colonoscopy. Methods: Participants were recruited from a nationwide multicenter trial in Japan to assess the accuracy of CTC detection.
Takashi Kato, Kiyotaka Sasaki, Koichi Nagata, Michiaki Hirayama, Shungo Endo, Shoichi Horita   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source