Results 71 to 80 of about 745,959 (309)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A patient and community-centered approach selecting endpoints for a randomized trial of a novel advance care planning tool

Patient Preference and Adherence, 2018
John FP Bridges,1,2 Norah L Crossnohere,2 Anne L Schuster,1 Judith A Miller,3 Carolyn Pastorini,3,† Rebecca A Aslakson2,4,5 1Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD ...
Bridges JFP, Crossnohere NL, Schuster AL, Miller JA, Pastorini C, Aslakson RA   +5 more
doaj  

Chinese Medicine for Chronic Obstructive Pulmonary Disease: A Pilot Study on Patient Preferences

Patient Preference and Adherence, 2021
Shaonan Liu,1 Jiaqi Lai,1 Lei Wu,2 Xinfeng Guo1 1Evidence-based Medicine & Clinical Research Service Group, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou ...
Liu S, Lai J, Wu L, Guo X
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Preferences and motivation for weight loss among knee replacement patients: implications for a patient-centered weight loss intervention

BMC Musculoskeletal Disorders, 2017
Background Most knee replacement patients are overweight/obese, yet are commonly excluded from evidence-based weight loss programs due to mobility limitations and barriers faced around the time of surgery.
Christine A. Pellegrini, Gwendolyn Ledford, Sara A. Hoffman, Rowland W. Chang, Kenzie A. Cameron   +4 more
doaj   +1 more source

Decision aids for people facing health treatment or screening decisions (Review) [PDF]

, 2009
Background Decision aids prepare people to participate in ’close call’ decisions that involve weighing benefits, harms, and scientific uncertainty. Objectives To conduct a systematic review of randomised controlled trials (RCTs) evaluating the efficacy ...
Adab, Armstrong, Auvinen, Auvinen, Barry, Bastian, Bekker, Bekker, Bekker, Bernstein, Briss, Brown, Brundage, Chadwick, Charles, Chewning, Clancy, Colella, Coulter, Crang-Svalenius, Davison, Davison, Deber, Deber, Degner, Deschamps, Deyo, Dodin, Dolan, Dunn, Elwyn, Emmett, Ende, Entwistle, Flood, Frosch, Frosch, Gafni, Gattellari, Gattellari, Godlee, Goel, Graham, Gravel, Green, Green, Green, Green, Greenfield, Gruppen, Gruppen, Hays, Healton, Herrera, Hewison, Hickish, Hochlehnert, Holloway, Holmes-Rovner, Hunt, Hunter, Hunter, Jadad, Johnson, Jorm, Kennedy, LaCroix, Lalonde, Laupacis, Lazcano Ponce, Legare, Lerman, Leung, Lewis, Llewellyn-Thomas, Maisels, Makoul, Man-Son-Hing, Manns, Markham, Martin, Maslin, Maslin, Mazur, McAlister, McBride, McGinley, McInerney-Leo, Michie, Miller, Molenaar, Molenaar, Montgomery, Morgan, Mulley, Mulley, Murray, Murray, Myers, Myers, Nagle, Newton, O'Cathain, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, Oakley, Partin, Pearson, Peele, Phelan, Phillips, Pignone, Proctor, Radloff, Ratliff, Rimer, Rimer, Roland, Roosmalen, Roosmalen, Rostom, Rothert, Rothert, Rovner, Ruland, Ryser, Schapira, Schwartz, Sepucha, Sheridan, Shorten, Sorenson, Spielberger, Stacey, Steiner, Stewart, Street, Street, Tabak, Thomson, Thornton, Valdez, Volk, Volk, Vuorma, Vuorma, Wagner, Wallston, Wang, Whelan, Whelan, Whitney, Willemsen, Wolf, Wolf, Wolf, Wong, Wroe, Zapka   +170 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Patient-initiated discharge from emergency departments and the related factors in Jiroft, South of Iran [PDF]

Journal of Holistic Nursing and Midwifery
Introduction: Patients’ self-discharge may indicate dissatisfaction with healthcare services. In some cases, it can lead to re-hospitalization or even the death of the patient.
Shima Groohi-sardou, Akbar Anaei Goudari, Vahid Rahmanian, Reza Faryabi, Najmeh Ghasemian, Ehsan Goroei Sardou, Salman Daneshi   +6 more
doaj  

Patient Preferences for Attributes of Biologic Treatments in Moderate to Severe Asthma: A Discrete Choice Experiment Study

Patient Preference and Adherence, 2022
Min Yang,1 Jingdong Chao,2 Mirko Fillbrunn,1 Usha G Mallya,3 Min-Jung Wang,1 Leigh Franke,1 Lauren Cohn,4,5 Siddhesh Kamat2 1Analysis Group, Inc, Boston, MA, USA; 2Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA; 3Sanofi, Boston, MA, USA; 4Section of ...
Yang M, Chao J, Fillbrunn M, Mallya UG, Wang MJ, Franke L, Cohn L, Kamat S   +7 more
doaj  

Patient treatment preferences for symptomatic refractory urodynamic idiopathic detrusor overactivity

Urology Annals, 2017
Introduction: There is a multiplicity of treatments currently available for patients with symptomatic refractory urodynamic idiopathic detrusor overactivity (SRU IDO).
Christina L Fontaine, Ian Rudd, Mahreen Pakzad, Rizwan Hamid, Jeremy L Ockrim, Tamsin J Greenwell   +5 more
doaj   +1 more source