Results 201 to 210 of about 10,695,329 (297)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Patient-reported outcome measures in cardiac surgery: A systematic review. [PDF]

JTCVS Open
Rosgen BK, Bele S, Ahmed S, Kemp K, Santana MJ, Gregory AJ.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Remote usage of digital patient-reported outcome measures for shoulder and elbow pathologies: a systematic review. [PDF]

JSES Rev Rep Tech
Lutz N, Käßer N, David J, Öttl F, Dey Hazra RO, Lazaridou A, Scheibel M, Rosso C, Back DA.   +8 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Comparative performance of common paediatric patient-reported outcome measures (P-PROMs) across health conditions. [PDF]

Arch Dis Child
Jones R, Devlin N, Dalziel K, O'Loughlin R, Mulhern B, White M, Shanthikumar S, Chen K, Silva M, Walkley E, Constable L, Hiscock H.   +11 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Development and Application of Patient-Reported Outcome Measures (PROMs) in Patients on Chronic Home Oxygen Therapy. [PDF]

J Clin Med
Chiner E, Boira I, Fernández-Serrano J, Llombart M, Esteban V, Fernández Martínez P, Fernández M, Vañes S, Gigliarano F, Navarro S, García Ferrer S.   +10 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Comparison of Patient Reported Outcome Measures and MCID Achievement in Patients With Radiculopathy Undergoing Open Versus MIS TLIF. [PDF]

Global Spine J
Ng M, Baek G, Miloh RY, Mathew J, Lee Y, Hitchner M, Green W, Eichbaum Y, Banko SJ, Patel K, Stump K, Uvarov EV, Farooqi A, Martinazzi B, Giakas A, Dalton J, Hilibrand AS, Vaccaro AR, Schroeder GD, Kepler CK.   +19 more
europepmc   +1 more source