Results 231 to 240 of about 1,479,071 (353)

Chiropractor perspectives on the use of patient reported outcome measures: a survey of Veterans Health Administration chiropractors. [PDF]

Chiropr Man Therap
Coleman BC, Brandt CA, Melnick ER, Kawecki T, Heapy A, Lisi AJ.   +5 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Self-completed patient-reported outcome measures in adults with epilepsy: A review. [PDF]

Epilepsia Open
Conquest AL, O'Brien TJ, Kwan P, French JA, Malpas CB, Foster EC.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Are Currently Available Joint-Specific Patient-Reported Outcome Measures Fit for Purpose to Assess the Outcome of Knee Arthroplasty? [PDF]

Cailin J. de Wet, Nick D. Clement, Tom Williamson   +2 more
openalex   +1 more source

Longitudinal evaluation of patient-reported outcome measures and clinician-based scores after reverse shoulder arthroplasty in Asian patients: patient-reported outcome measures may be sufficient beyond 1 year. [PDF]

JSES Int
Hirakawa Y, Manaka T, Nakazawa K, Ito Y, Ogura A, Takahashi Y, Hasegawa Y, Igawa A, Terai H.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A comparison of in-the-moment and retrospective patient-reported outcome measures in advanced cancer. [PDF]

Support Care Cancer
Geeraerts J, de Nooijer K, Pivodic L, Crombez G, Decoster L, Fontaine C, Joris S, Naert E, De Ridder M, Van den Block L.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Persistent Postmastectomy Pain: A Comparison of Diagnosis and Patient-reported Outcome Measures in 6988 Patients. [PDF]

Plast Reconstr Surg Glob Open
Rochlin DH, Levy J, Kim M, Boe L, Mehrara BJ, Nelson JA.   +5 more
europepmc   +1 more source