Results 221 to 230 of about 1,479,071 (353)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Use of patient-reported outcome measures after breast reconstruction in low- and middle-income countries: a scoping review

Sri Harshini Malapati, Maria Orlando Edelen, Gita N. Mody, Andrea L. Pusic, Amanda Fazzalari, Colby J. Hyland, George Liang, Manraj Kaur, Paul Bain   +8 more
openalex   +1 more source

Clinical events and patient-reported outcome measures during CKD progression: findings from the Chronic Renal Insufficiency Cohort Study

, 2020
Morgan E. Grams, Aditya Surapaneni, Lawrence J. Appel, James P. Lash, Jesse Y. Hsu, Clarissa J. Diamantidis, Sylvia E. Rosas, Jeffrey C. Fink, Julia J. Scialla, James Sondheimer, Chi‐yuan Hsu, Alfred K. Cheung, Bernard G. Jaar, Sankar D. Navaneethan, Debbie L. Cohen, Sarah J. Schrauben, Dawei Xie, P. Jagannadha Rao, Harold I. Feldman, the CRIC study investigators, Alan S. Go, Jiang He, Mahboob Rahman, Raymond R. Townsend   +23 more
openalex   +2 more sources

The Use of Patient-Reported Outcome Measures in Paediatric Haematopoietic Stem Cell Transplant: A Systematic Review. [PDF]

Children (Basel)
Penny R, Keogh S, Shergold J, Bradford N.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Unlocking patient insights: a prospective study on patient reported outcome measures in thoracic surgery. [PDF]

J Cardiothorac Surg
Andreas MN, Jurth C, Schmid JC, Weber LM, von Dincklage F, Lask A, Strauchmann J, Pratschke J, Rückert JC, Neudecker J, Dziodzio T.   +10 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Patient-Reported Outcome Measures in Fetal Medicine: A Pilot Feasibility Study. [PDF]

Prenat Diagn
Crombag NMTH, Teeuwen B, Akkerman EMP, Adriaanse BME, Depla AL, Franx A, Oerlemans AJM, Stemkens D, Henneman L, Bekker MN.   +9 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

MOESM1 of Haematologists’ experiences implementing patient reported outcome measures (PROMs) in an outpatient clinic: a qualitative study for applied practice

, 2019
Stine Thestrup Hansen, Mette Kjerholt, Sarah Friis Christensen, Bibi Hølge-Hazelton, John Brodersen   +4 more
openalex