Results 121 to 130 of about 5,862,677 (310)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The knowledge and opinions of maternity wards patients in Kielce on the patient rights

Journal of Education, Health and Sport, 2017
Introduction: A legal and ethical obligation of a midwife is to inform patients about their rights in the course of therapeutic and nursing care and to respect these rights in practice.
Marzena Wrześniewska, Olga Adamczyk-Gruszka, Jakub Gruszka, Karolina Komar-Gruszka, Beata Bąk   +4 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A meaningful Human Rights Council in 2030: Catalyse National Rights Protection

, 2016
Rather than celebrating the 10th anniversary of the UN Human Rights Council, we should take a moment to reflect upon what must be improved. This applies not only to States but also to civil society.
Kletzel, Gabriela, Lugon Arantes, Paulo de Tarso, Asano, Camila, Quintanilla, Daniela   +3 more
core  

Qualitative study on the construction of nursing ethics standards in multiculturalism of Macao

Huli yanjiu
ObjectiveTo explore the necessity and needs for developing a code of ethics for nurses in the multicultural context of Macao, and to provide a scientific basis for the construction of nursing ethical standards.MethodsA phenomenological research approach ...
GAO Ya, LUO Zhimin
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Rights and obligations of the patients in the primary health care

Journal of Education, Health and Sport, 2019
The rights patient as a set of rights due to the use of health services in Poland result from the Constitution of the Republic of Poland. They are regulated by the whole regulations.
Alicja Marzec, Agnieszka Pluta, Kamila Faleńczyk, Maria Budnik-Szymoniuk, Marta Lewicka   +4 more
doaj  

"It's like asking for a necktie when you don't have underwear": Discourses on patient rights in southern Karnataka, India. [PDF]

Int J Equity Health, 2023
Putturaj M, Van Belle S, Krumeich A, Ns P, Engel N.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source