Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Resuscitating Patient Rights during the Pandemic: COVID-19 and the Risk of Resurgent Paternalism. [PDF]
Camb Q Healthc Ethics, 2021 Fins JJ.
europepmc +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Patients’ Attitude toward Breaking Bad News; a Brief Report
Emergency, 2016 Introduction: Delivering bad news is a stressful moment for both physicians and patients. The purpose of this investigation was to explore the patients’ preferences and attitudes toward being informed about the bad news.
Hamed Aminiahidashti +2 more
doaj
Physician autonomy and patient rights: lessons from an enforced blood transfusion and the role of patient blood management. [PDF]
Vox Sang, 2021 Bolcato M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Investigating the extent of compliance with patient rights by dental students from the perspective of patients referring to the Ilam Dental School Clinic in 2024 [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i ĪlāmIntroduction: Patient rights as an ethical principle include meeting the acceptable physical, psychological, spiritual and social needs of the patient, which are supported by the national laws and regulations of each country.
Mostafa Mirabizadeh +4 more
doaj
[Patient rights in the context of complaint management-Right of access to the medical records]. [PDF]
Orthopade, 2021 Schwarze M +3 more
europepmc +1 more source
The Right Device for the Right Patient at the Right Time
Circulation Journal, 2021 openaire +3 more sources