Results 231 to 240 of about 2,678,438 (292)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Optimizing Collagen Biostimulator Choice in LATAM: Expert Consensus on Patient Selection, Ethnic Skin Phenotypes, and Accessibility. [PDF]

J Cosmet Dermatol
Cure E, Hernández LAP, Amado AM, Cabrales JSR, Garcés E, Dicker V, Castelanich D, Schneider C, Salas I, Argueta J, Tafur LV, Acevedo A, Bugallo A, Murúa E, Hernandez AMP.   +14 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection. [PDF]

Brain Sci
Vernik D, Payne C, Sinha K, Martinez C, Jungbauer WN, Jeger JL, Bohl M, Ropper AE, Winocour S, Reece E.   +9 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Who benefits from multidisciplinary care in functional somatic disorders? Identifying cost-effective patient selection through diagnostic classification groups. [PDF]

Isr J Health Policy Res
Hammerman O, Rasooly A, Greenberg D, Kushnir T, Yaakobi E, Ezra Y.   +5 more
europepmc   +1 more source

Anti-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Evidence, ARIA Risk, and Precision Patient Selection. [PDF]

J Pers Med
Alkhalifa AE, Al Mokhlf A, Ali H, Al-Ghraiybah NF, Syropoulou V.   +4 more
europepmc   +1 more source

MRI-based patient selection for active surveillance in prostate cancer using U-Found: a generalized deep learning model. [PDF]

Cancer Imaging
Lowry NC, Breto AL, Wallaengen V, Algohary A, Tapia-Stoll N, Gaston SM, Prakash NS, Freitas PFS, Kryvenko ON, Castillo P, Saltz J, Kurc T, Ritch CR, Nahar B, Gonzalgo ML, Parekh DJ, Mahal B, Spieler BO, Pra AD, Abramowitz MC, Pollack A, Punnen S, Stoyanova R.   +22 more
europepmc   +1 more source

Patient Selection for Revascularization of Atherosclerotic Renal Artery Stenosis: Comparing the Importance of Stenosis Severity and Clinical Phenotype. [PDF]

Kidney Med
Green D, Cleland JGF, O'Keeffe H, Chinnadurai R, Lake E, Chrysochou C, Kalra PA.   +6 more
europepmc   +1 more source