Results 221 to 230 of about 6,688,553 (311)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Food oral immunotherapy patient selection, dosing, and monitoring practices among a network of US food allergy centers. [PDF]

J Allergy Clin Immunol Pract
Ponda P, Bird JA, Bufford JL, Cianferoni A, Faig W, Kleiner GI, Lang A, Scurlock AM, Shreffler WG, Varshney P, Food Allergy Research & Education Clinical Network Site Authors, Sicherer SH, Assa'ad A.   +12 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Patient selection and toxicity predictors in proton reirradiation for locoregional breast cancer recurrence. [PDF]

Clin Transl Radiat Oncol
Chakraborty MA, White C, Khan AJ, Yang S, Zhang Z, Yu F, Lin H, Braunstein LZ, Roth O'Brien D, Cuaron JJ, Guttmann DM, LaPlant Q, Powell SN, Cahlon O, Choi JI.   +14 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Local excision for anal squamous cell carcinoma: challenges in patient selection and diagnosis. [PDF]

Arq Bras Cir Dig
Sobrado LF, Mendes GC, Nahas CSR, Cotti GCC, Imperiale AR, Soares DFM, Marques CFS, Ribeiro Junior U.   +7 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Pretreatment feeding‑stoma placement in advanced esophageal cancer: defining optimal patient selection criteria. [PDF]

Esophagus
Chiang HC, Chiang CM, Chen YY, Wu SY, Lin FC, Pao TH, Chung TJ, Sheu BS, Chang WL.   +8 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Revisiting patient selection and treatment planning in the VIOLETTE trial of targeted microwave ablation. [PDF]

BJU Int
Roldan-Testillano R, Hussain JM, Wiryadi A, Sanchez-Salas R.   +3 more
europepmc   +1 more source