Results 41 to 50 of about 217,141 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

From Algorithms to Empathy: Exploring Chatbots as Tools for Medical Student Training [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences
This commentary examines the emerging role of conversational chatbots in medical education, particularly in terms of educating learners in empathy. Empathy is a key professional skill that impacts deeply both patient outcomes and patient satisfaction ...
Zahra Karimian, Farzaneh Ghaznavi
doaj   +1 more source

Improving Perinatology Residents’ Skills in Breaking Bad News: A Randomized Intervention Study [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2018
Objective Breaking bad news (BBN) is particularly difficult in perinatology. Previous research has shown that BBN skills can be learned and improved when taught and practiced.
Maria Silvia Vellutini Setubal, Maria Ângela Reis Goes Monteiro Antonio, Eliana Martorano Amaral, John Boulet   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Medicine and motherhood: a cross-sectional survey of the experiences of women doctors in the Republic of Ireland

BMC Women's Health
Background Women doctors may face challenges in their pursuit of motherhood, including a higher likelihood of delayed childbearing and infertility. The psychological and financial sequelae of their experiences around fertility, pregnancy, and motherhood ...
Sanjana Biju, Caoimhe Madden, Paul O’Connor, Dara Byrne, Niamh Humphries, Sarah Fitzgibbon, Jennifer Finnegan, Keelin O’Donoghue, Grant Jeffrey, Sinéad Lydon   +9 more
doaj   +1 more source

Principles for the conduct of human factors/ergonomics in healthcare: a scoping study of the published evidence

BMJ Open Quality
Background There is a need for guidance to support human factors/ergonomics (HFE) practitioners to conceive and design HFE interventions that live up to the fundamental principles underpinning the discipline of HFE.
Marie E Ward, Paul O’Connor, Angela O’Dea, Mahnaz Sharafkhani, Margaret Codd, Mary Browne   +5 more
doaj   +1 more source

Simulated patient for orthognathic surgery [PDF]

Proceedings Computer Graphics International 2000, 2002
Orthognathic surgery corrects a wide range of minor and major facial and jaw irregularities. This surgery will improve the patients' ability to chew, speak and breathe. In many cases, a better appearance will also result. With the recent advances in virtual reality (VR) and three-dimensional (3D) medical imaging technology, orthognathic surgery ...
Horace Ho-Shing Ip, Christy S. B. Kot, James J. Xia   +2 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of a labour and delivery simulated practice programme for elderly primigravidas

Nursing Open, 2020
Aim Increasing numbers of older gravidas compel research into best practices for their labour‐related outcomes. Responding to this need, this study sought to develop and evaluate a programme for older primigravidas.
Chun hee Seong, Kyung min Park, Kyoung ja Moon   +2 more
doaj   +1 more source

Four-Dimensional Superimposition Techniques to Compose Dental Dynamic Virtual Patients: A Systematic Review

Journal of Functional Biomaterials, 2023
Four-dimensional virtual patient is a simulation model integrating multiple dynamic data. This study aimed to review the techniques in virtual four-dimensional dental patients. Searches up to November 2022 were performed using the PubMed, Web of Science,
Ying Yuan, Qian Liu, Shuo Yang, Wulin He
doaj   +1 more source