Results 41 to 50 of about 5,953,552 (258)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Evaluating telemedicine: A focus on patient pathways [PDF]

open access: yes, 2006
Evaluations of telemedicine have sought to assess various measures of effectiveness (e.g., diagnostic accuracy), efficiency (e.g., cost), and engagement (e.g., patient satisfaction) to determine its success.
Eatock, J   +8 more
core   +1 more source

Addressing under-appreciated risk in healthcare simulation

open access: yesAdvances in Simulation
Our experience of running a simulation centre reveals specific areas of risk that are not widely discussed in the simulation literature- namely the potential for physical harm and threats to the viability and continuity of simulation programmes. Physical
Paul O’Connor   +2 more
doaj   +1 more source

Comparison of the effects of simulated patient clinical skill training and student roleplay on objective structured clinical examination performance among medical students in Australia [PDF]

open access: yesJournal of Educational Evaluation for Health Professions, 2019
Purpose Optimal methods for communication skills training (CST) are an active research area, but the effects of CST on communication performance in objective structured clinical examinations (OSCEs) has not been closely studied. Student roleplay (RP) for
Silas Taylor   +2 more
doaj   +1 more source

Interdisciplinary Education Apartment Simulation (IDEAS) Project: An Interdisciplinary Simulation for Transitional Home Care

open access: yesMedEdPORTAL, 2021
Introduction Home-based care (HBC) is a valuable tool to provide care to rural, medically underserved populations. By mitigating geographic and transportation barriers for vulnerable populations, HBC is a promising modality of health care delivery ...
Jenna N. Sizemore   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Technology about me without me: An examination of the relationship between patient-facing technology and patient experience [PDF]

open access: yes, 2022
To appreciate the role of electronic health records (EHRs) in achieving the goals of patient-centered care, scholars have focused primarily on the influence of EHR capabilities on clinical providers’ behaviors.
Haun, Courtney N, PhD, MPH   +1 more
core   +1 more source

MEDICAL, LEGAL AND ECONOMIC ASPECTS TO DIAGNOSE SELFMUTILATION, IMITATING DELIBERATE ACUTE SURGICAL PATHOLOGY. CLINICAL CASE

open access: yesКреативная хирургия и онкология, 2017
Introduction. To date, in penal institutions of the Russian Federation annually there are not less than 10000 accurately registered facts of self-mutilation, causing immediate or delayed medical care in terms of surgical hospital.
Andrey V. Vasilchenko, Albert M. Gareev
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Exploring Experiences of Psychiatric Nursing Simulations Using Standardized Patients for Undergraduate Students

open access: yesAsian Nursing Research, 2012
Purpose: This study was conducted to explore and understand the experiences of nursing students related to psychiatric simulation using standardized patients and to identify the value of such simulations in relation to the psychiatric clinical practicum.
Yun-Jung Choi, PhD, RN, PMHNP
doaj   +1 more source

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