Results 51 to 60 of about 5,953,552 (258)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

From Algorithms to Empathy: Exploring Chatbots as Tools for Medical Student Training [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences
This commentary examines the emerging role of conversational chatbots in medical education, particularly in terms of educating learners in empathy. Empathy is a key professional skill that impacts deeply both patient outcomes and patient satisfaction ...
Zahra Karimian, Farzaneh Ghaznavi
doaj   +1 more source

Improving Perinatology Residents’ Skills in Breaking Bad News: A Randomized Intervention Study [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2018
Objective Breaking bad news (BBN) is particularly difficult in perinatology. Previous research has shown that BBN skills can be learned and improved when taught and practiced.
Maria Silvia Vellutini Setubal, Maria Ângela Reis Goes Monteiro Antonio, Eliana Martorano Amaral, John Boulet   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The patient patient: The importance of knowing your navigator [PDF]

, 2015
In Ontario, Diagnostic Assessment Programs (DAPs) have been implemented to improve the quality of care patients receive during the diagnostic phase of the cancer journey.
Kaan, Melissa, MBA, Holloway, Claire MB, MD PhD FRCSC, Gilbert, Julie E, PhD, Klonikowski, Eric, Wheeler, Sarah M, PhD   +4 more
core   +1 more source

Medicine and motherhood: a cross-sectional survey of the experiences of women doctors in the Republic of Ireland

BMC Women's Health
Background Women doctors may face challenges in their pursuit of motherhood, including a higher likelihood of delayed childbearing and infertility. The psychological and financial sequelae of their experiences around fertility, pregnancy, and motherhood ...
Sanjana Biju, Caoimhe Madden, Paul O’Connor, Dara Byrne, Niamh Humphries, Sarah Fitzgibbon, Jennifer Finnegan, Keelin O’Donoghue, Grant Jeffrey, Sinéad Lydon   +9 more
doaj   +1 more source

Principles for the conduct of human factors/ergonomics in healthcare: a scoping study of the published evidence

BMJ Open Quality
Background There is a need for guidance to support human factors/ergonomics (HFE) practitioners to conceive and design HFE interventions that live up to the fundamental principles underpinning the discipline of HFE.
Marie E Ward, Paul O’Connor, Angela O’Dea, Mahnaz Sharafkhani, Margaret Codd, Mary Browne   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Assessing human factors during simulation: The development and preliminary validation of the rescue assessment tool [PDF]

, 2014
Background: Failure to rescue the deteriorating patient is a concern for all healthcare providers. In response to this problem providers have introduced a range of interventions to promote timely rescue. Human factors and non-technical skills play a part
Melling, Andrew, Tucker, Guy, Unsworth, John, Allan, Jaden, Kelleher, Michael   +4 more
core   +1 more source

Effects of a labour and delivery simulated practice programme for elderly primigravidas

Nursing Open, 2020
Aim Increasing numbers of older gravidas compel research into best practices for their labour‐related outcomes. Responding to this need, this study sought to develop and evaluate a programme for older primigravidas.
Chun hee Seong, Kyung min Park, Kyoung ja Moon   +2 more
doaj   +1 more source