Results 111 to 120 of about 15,627,075 (282)

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Sudden unexpected physicians’ death during performing professional duties: increasing social and public health problem

International Journal of Occupational Medicine and Environmental Health
A work-related death from sudden causes among physicians is not a new problem although still not enough explored in the scientific literature. Estimating the scale of the phenomenon is important from a social and public health point of view.
Jolanta Bilińska, Joanna Ruszkowska, Hussain Jafri, Wojciech Drygas   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A Communal Vision of Care for Incompetent Patients

, 1987
In a pluralistic society, the "best interest" standard is an inadequate criterion for determining what level of medical care to provide incompetent patients.
Emanuel, Ezekiel J.
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development and psychometric validation of the PERQOLATEUR questionnaire: an individualized self-report measure of the impact of chronic illness and treatment in clinical practice

Journal of Patient-Reported Outcomes
Background Quality of life is a key construct in healthcare, particularly in the concept of health-related quality of life (HRQoL). Existing questionnaires are widely used in research but remain underused in clinical practice, partly due to their length ...
Jean-Benoit Hardouin, Djuly Pierre-Paul, Anne Le Rhun, Philippe Tessier, Marianne Bourdon, Leila Moret   +5 more
doaj   +1 more source

Results of environmental monitoring at pediatrics isolation ward, tertiary hospital in northern of Thailand

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Throughout healthcare, the physical environment presents an important source of pathogens that can cause healthcare associated infections (HAIs) To keep patients safe, hospitals must maintain a clean environment and minimize the presence of ...
Sutthiphan Thanomphan, Mattana Chaiprasert, Nittaya Wungsudthisomsri   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source