Results 71 to 80 of about 67,249 (274)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Effect of Patronage Politics on City Government in American Cities, 1900-1910 [PDF]
In this paper I explore the effect of patronage or machine' politics on government performance in American cities during the Progressive era. I use game theoretic models and an empirical analysis of spending and public goods provision during the first ...
Rebecca Menes
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 1909 Variante(s) de titre : Le Trait d'union du Patronage Saint-SépulcreAppartient à l’ensemble documentaire : NordPdeC1Avec mode ...
Patronage Saint-Sépulcre. Auteur du texte
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CepaloThis study offers a comparative analysis of the recognition and protection of indigenous land and natural resource rights within the Environmental, Social, and Governance (ESG) framework in Indonesia and Thailand.
Muh. Zulkifli Muhdar +3 more
doaj +1 more source
Le roi, les lettres, les étrangers : remarques sur quelques représentations textuelles (1600-1630)
Bulletin du Centre de Recherche du Château de Versailles, 2006 Foreign figures, mainly Italian, played an important role in development of the representation of the king of France as protector of the arts. With the coming of the Bourbons and the arrival in the kingdom of a foreign queen, Marie de’ Medici, this ...
Bruno Petey-Girard
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2009 Patronage, expansively conceived as covering all forms of bias and discrimination, is pervasive in organisations and professions, including academia. Four key types of academic patronage operate through decisions made, processes used, assistance given to
Brian Martin (19588423)
core +2 more sources