Results 101 to 110 of about 2,595,399 (242)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

PEPR1 Mediates SsNLP1-Triggered Immunity Against Sclerotinia sclerotiorum

Necrosis- and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) are conserved microbial proteins that contain immunogenic patterns capable of activating plant pattern-triggered immunity (PTI).
Xin-Zhong Cai, Zeeshan Ghulam Nabi Gishkori, Muhammad Kamran, Imtiaz Ahmad Sajid   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Convergent and Divergent Signaling in PAMP-Triggered Immunity and Effector-Triggered Immunity

, 2018
Plants use diverse immune receptors to sense pathogen attacks. Recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors localized on the plasma membrane leads to PAMP-triggered immunity (PTI).
Yujun Peng, Rowan van Wersch, Yuelin Zhang   +2 more
core   +1 more source

Functional analysis of RALF peptides in soybean immunity and disease resistance

Phytopathology Research
Plant cell-surface-localized pattern-recognition receptors (PRRs) recognize conserved microbial patterns to activate pattern-triggered immunity (PTI), which confers mild and broad-spectrum resistance to most microbes.
Weijie Wang, Zhuoyuan He, Dongmei Wang, Guangyuan Xu, Jun Yang, Xianzhong Feng, Xiangxiu Liang, Daolong Dou, Rubin Chen   +8 more
doaj   +1 more source

COP9 Signalosome’s Role in Plant Defense Mechanisms

Plants
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex that plays a crucial role in plant growth, development, and stress responses by modulating the ubiquitination pathway.
Zihua Lu, Chao Li, Kelin Deng, Cong Han, Zhihui Shan, Shuilian Chen, Hongli Yang, Yuanxiao Yang, Haifeng Chen, Qingnan Hao   +9 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia Sclerotiorum

, 2013
Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia ...
尹恒, 卢航, 杜昱光, 李艳, 赵小明, 张洪艳, 王文霞, Grevsen K   +7 more
core  

A peptide-receptor module links cell wall integrity sensing to pattern-triggered immunity

Plants employ cell-surface receptors to perceive non- or altered-self, including the integrity of their cell wall. Here we identify a specific ligand–receptor module responsive to cell wall damage that potentiates immunity in Arabidopsis.
Zipfel, Cyril, Rhodes, Jack, Zhai, Keran
core   +1 more source

Discovery of functional PRRs for the fungal elicitor Xyn11/eix in Prunus fruit trees

Plant Stress
Pattern-triggered immunity (PTI) is a critical defense mechanism employed by plants against pathogen attacks. This study explores the role of PTI induced by the Xyn11/eix fungal elicitor in two commercially valuable Rosaceae species, Prunus persica ...
Andree Alvarez, Uri Aceituno-Valenzuela, Meirav Leibman-Markus, Daniela Muñoz, Carlos Rubilar, Franco Figueroa, Manuel Pinto, Mauricio Latorre, Claudia Stange, Adi Avni, Maya Bar, Lorena Pizarro   +11 more
doaj   +1 more source