Results 101 to 110 of about 3,086,681 (240)

Brassinosteroids inhibit pathogen-associated molecular pattern–triggered immune signaling independent of the receptor kinase BAK1

, 2011
Plants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs ...
Rathjen, John P, Albrecht, Catherine, Boutrot, Freddy; https://orcid.org/, Segonzac, Cécile; https://orcid.org/, Zipfel, Cyril; https://orcid.org/, Chinchilla, Delphine, de Vries, Sacco C, Schwessinger, Benjamin, Gimenez-Ibanez, Selena   +8 more
core   +2 more sources

AvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunity.

PLoS Pathogens, 2014
Bacterial pathogens of plant and animals share a homologous group of virulence factors, referred to as the YopJ effector family, which are translocated by the type III secretion (T3S) system into host cells during infection.
Mi Sun Cheong, Angela Kirik, Jung-Gun Kim, Kenneth Frame, Viktor Kirik, Mary Beth Mudgett   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia Sclerotiorum

, 2013
Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia ...
尹恒, 卢航, 杜昱光, 李艳, 赵小明, 张洪艳, 王文霞, Grevsen K   +7 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

DataSheet_1_The Lamin-Like LITTLE NUCLEI 1 (LINC1) Regulates Pattern-Triggered Immunity and Jasmonic Acid Signaling.pdf

, 2020
Pathogen-associated molecular pattern (PAMP) recognition occurs by plasma membrane located receptors that induce among other processes nuclear gene expression.
Kiruthiga Mariappan (3864430), Marilia Almeida-Trapp (8273109), Mai Jarad (8273106), Naganand Rayapuram (1826515), Michael Florian Mette (8273112), Heribert Hirt (30710), Axel Mithöfer (699485)   +6 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Functional analysis of RALF peptides in soybean immunity and disease resistance

Phytopathology Research
Plant cell-surface-localized pattern-recognition receptors (PRRs) recognize conserved microbial patterns to activate pattern-triggered immunity (PTI), which confers mild and broad-spectrum resistance to most microbes.
Weijie Wang, Zhuoyuan He, Dongmei Wang, Guangyuan Xu, Jun Yang, Xianzhong Feng, Xiangxiu Liang, Daolong Dou, Rubin Chen   +8 more
doaj   +1 more source

COP9 Signalosome’s Role in Plant Defense Mechanisms

Plants
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex that plays a crucial role in plant growth, development, and stress responses by modulating the ubiquitination pathway.
Zihua Lu, Chao Li, Kelin Deng, Cong Han, Zhihui Shan, Shuilian Chen, Hongli Yang, Yuanxiao Yang, Haifeng Chen, Qingnan Hao   +9 more
doaj   +1 more source