Results 151 to 160 of about 3,086,681 (240)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Improving the Diagnostic Accuracy of Plasma Alzheimer's Disease Biomarkers With Objective and Subjective Cognitive Screening

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined whether plasma biomarkers differ in
Maryam Abdolmaleki, Leslie S. Gaynor, Dandan Liu, Timothy J. Hohman, Katherine A. Gifford, Henrik Zetterberg, Angela L. Jefferson, Corey J. Bolton   +7 more
wiley   +1 more source

CRISPR/Cas9-based knockout of BnaLYK compromises pattern-triggered immunity and resistance to Sclerotinia sclerotiorum in Brassica napus. [PDF]

BMC Plant Biol
Liu Y, Yin X, Jin P, Zhang H.
europepmc   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Proteomic snapshot of pattern triggered immunity in the Arabidopsis leaf apoplast. [PDF]

Plant J
Chen HC, Newton CJ, Diaz G, Zheng Y, Kong F, Yao Y, Yang L, Kvitko BH.   +7 more
europepmc   +1 more source

LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants

Pattern-recognition receptor (PRR)-triggered immunity (PTI) wards off a wide range of pathogenic microbes, playing a pivotal role in angiosperms. The model liverwort Marchantia polymorpha triggers defense-related gene expression upon sensing components ...
シラカワ, マコト, Shirasu, Ken, Michavila, Santiago, Yotsui, Izumi, Nishihama, Ryuichi, Ibanez, Selena Gimenez, Iwakawa, Hidekazu, Nomura, Yuko, Ichihashi, Yasunori, Kohchi, Takayuki, Nakagami, Hirofumi, Miyauchi, Shingo, 13, Yan, Yijia, Matsui, Hidenori, Harzen, Anne, 白川, 一, Melkonian, Katharina, Sugano, Shigeo S., Jeon, Hyung-Woo, Shirakawa, Makoto, Schl$00FCter, Titus, Kanazawa, Takehiko, Stolze, Sara Christina, Ueda, Takashi   +24 more
core  

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Pattern-triggered immunity in blue and white seed cultivars of <i>Papaver somniferum</i>. [PDF]

AoB Plants
Hernández Orozco JS, Iakovenko O, Zeiner A, Hronková M, Kubásek J, Kučerová B, Vachová I, Pop S, Hradecká N, Maršík P, Macho M, Fojtíková P, Rychlá A, Hejna O, Kulich I, Wrzaczek M, Janda M.   +16 more
europepmc   +1 more source

Correction: Pathogen-associated molecular pattern-triggered immunity and resistance to the root pathogen Phytophthora parasitica in Arabidopsis. [PDF]

J Exp Bot, 2023
europepmc   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source