Results 31 to 40 of about 121,065 (257)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Antagonistic histone post-translational modifications improve the fidelity of epigenetic inheritance - a Bayesian perspective

Epigenetics & Chromatin
Background Histone Post-Translational Modifications (PTMs) are important epigenetic marks, whose specific pattern over the chromatin plays a critical role in turning the corresponding gene on/off. During DNA replication in mitotic cells, the histone PTMs
B. N. Balakrishna Prabhu, Aditya Naman Soni, Sibi Raj B. Pillai, Nithya Ramakrishnan   +3 more
doaj   +1 more source

High-fidelity patterning of AlN and ScAlN thin films with wet chemical etching

Materialia, 2022
We report on the anisotropic wet etching of sputtered AlN and Sc0.2Al0.8N thin films. With tetramethyl ammonium hydroxide at 80 °C, the etch rates along the c-axis were 330 and 30 nm/s for AlN and Sc0.2Al0.8N, respectively. Although the etching was anisotropic, significant lateral etching below the mask occurred, perpendicular to the c-axis.
Mertin, Stefan, Likonen, Jari, Hartikainen, Enni, Mizohata, Kenichiro, Dekker, James R., Thanniyil Sebastian, Abhilash, Pensala, Tuomas, Airola, Konsta   +8 more
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Site fidelity, size, and morphology may differ by tidal position for an intertidal fish, Bathygobius cocosensis (Perciformes-Gobiidae), in Eastern Australia [PDF]

PeerJ, 2016
The intertidal zone is a transitional environment that undergoes daily environmental fluctuations as tides rise and fall. Relatively few fish species are adapted to endure the physiological pressures of this environment. This study focused on Bathygobius
Lucie A. Malard, Katrina McGuigan, Cynthia Riginos   +2 more
doaj   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A Design Framework for 3-D Ceramic Patterns Combining an Optimized 3DGS-PBR Model and Kansei Engineering

IEEE Access
Chinese ceramic patterns, as treasured elements of intangible cultural heritage, have long faced three major challenges in the process of mapping onto 3D digital models: geometric misalignment on curved surfaces, visual-perceptual distortion under multi ...
Zhenlei Zhu, Jiangbo Liao
doaj   +1 more source

Spatial and temporal distribution of Gymnorhamphichthys rondoni (Gymnotiformes: Rhamphichthyidae) in a long-term study of an Amazonian terra firme stream, Leticia - Colombia [PDF]

Neotropical Ichthyology, 2019
Weakly electric fishes continually emit electric organ discharges (EOD) as a means of communication and localization of objects in their surroundings.
Carolina Escamilla-Pinilla, José Iván Mojica, Jorge Molina   +2 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source